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한국인(韓國人)의 식염(食鹽) 및 질소대사(窒素代謝)에 관(關)하여
정순동(Chung, Soon-Tong),양일석(Yang, Il-Suk) 대한생리학회 1967 대한생리학회지 Vol.1 No.2
In order to study the daily metabolism of sodium chloride and of nitrogen, 24 hour urine samples were collected from 298 normal Korean males whose ages varied Iron 26 to 80 years old. The volume and the concentration of chloride and the total nitrogen were determine, along with the resting pulse and the blood pressure. The daily urine volume was maintained at approximately 1,000ml/m<sup>2</sup> in all age groups while the chloride concentration was at approximately 230 mEq/l. Hence the daily urinary output of sodium chloride was estimated to be approximately 21 gm. On the other hand, the daily urinary output of total nitrogen amounted to approximately 10 gm. Theses findings are similar to those obtained earlier by Yi et al. (1966) in Korean subjects younger than 25 fears old, indicating that average Koreans live on low protein and high salt diets throughout their life. Despite a known correlation between the incidence of hypertension and the high salt intake, none of the these subjects employed in the present investigation showed any sign of hypertension.
가토신피질절편(家兎腎皮質切片)에서의 유기산이동(有機酸移動)에 관(關)한 연구(硏究) -특(特)히 전해질(電解質)의 영향(影響)에 대(對)하여-
정순동(Chung, Soon-Tong) 대한생리학회 1968 대한생리학회지 Vol.2 No.1
The uptake of phenolsulfonphthalein (PSP) and of paraaminohippuric acid (PAH) by cortical slices of the rabbit kidney was investigated while varying the composition of medium. The overall uptake of these substances displayed typical active transport characteristics and was significantly enhanced in presence of acetate. When the phosphate buffer was used the optimal pH was 7.4 for both substances. However, when the tris-buffer was used the optimal pH was 7.4 for PSP and 8.3 for PAH. Removal of Na<sup>+</sup> from the medium resulted in a significant reduction in the uptake. Similar results, though lesser in magnitude, were obtained when either K<sup>+</sup> or Ca<sup>++</sup> was removed from the medium. However, there was no additive effect when K<sup>+</sup> and/or Ca<sup>++</sup> were additionally removed from the Na<sup>+</sup>-free medium. The presence of NH<sub>4</sub><sup>+</sup> greatly reduced while Li<sup>+</sup> and Mg<sup>++</sup> moderately reduced the uptake of both substances. However, choline had no effect. In substrate-leached slices, acetate greatly enhance the uptake of organic acids; but this action was not demonstrable in absence of Na<sup>+</sup>, K<sup>+</sup> or Ca<sup>++</sup>.