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탯줄의 와튼젤리로부터 유래된 중간엽 줄기세포의 멜라닌 세포로의 분화
전송희 ( Song Hee Jeon ),김지영 ( Ji Young Kim ),정경아 ( Kyung Ah Cheong ),이애영 ( Ai Young Lee ) 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.3
Mesenchymal stem cells (MSCs) have been developed from different adult tissues and considered an important source of stem cells for cell therapy and regeneration. In this study, we demonstrate that MSCs in Wharton`s Jelly of human umbilical cord grown in melanocyte growth medium including stem cell factor (SCF) and endothelin -3 (ET-3) generate melanocyte precursor cells with a higher expression of melanocyte specific isoform of the microphtalmia transcription factor M (MITF-M), and TRP1, but not tyrosinase, terminal differentiation marker melanocytes. Although, in this condition, tyrosinase expression was not detected by using RT-PCR method in whole cells, a few MSCs showed tyrosinase positive in the immunostaining method. In conclusion, in this study, we demonstrated a possibility that human MSC in Wharton`s Jelly of human umbilical cord may be derived to human melanocyte-precursor cells.