http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
흰쥐 좌골신경에 신경파괴제 주입 후 초래되는 하지 운동과 신경조직학적 변화
전재규(Jae Kyu Cheun),송선옥(Sun Ok Song),정성원(Sung Won Jung) 대한통증학회 2001 The Korean Journal of Pain Vol.14 No.1
N/A Background: This study was undertaken to observe the functional changes of the hind limb and histopathological changes in the sciatic nerve after an injection of alcohol or phenol, which are commonly used neurolytic agents, highlighting the time of recovery. Methods: Forty-eight Sprague-Dawley rats weighing 200-300g were used for the experiment. Histopathological changes under the electron microscope, were observed in the distal part of the sciatic nerve, into which O. 1 ml of alcohol or phenol was injected. This was severed in 3 rats of each group at 10 minutes, 1 hour, 24 hours, 3 days, 1, 2, 4 and 6 weeks later. The functional changes in the hind limbs were observed for 6 weeks by noting their walking pattern. Results: Following the injection of alcohol or phenol into the right sciatic nerve, the right hind limb showed a severe pronounced motor weakness and obvious gait changes. About 2 weeks later, gradual improvement of gait changes began, and after 6 weeks, the motor weakness and gait changes were no longer perceptible in both groups. The findings of any histopathological change were similar in both alcohol or phenol groups. At 10 minutes after injection, destructive lesions were confined to the immyelinated fibers and the myelin sheath of small the myelinated fibers. On the 3rd day and at 1 week, pathologic changes in axonal fibers and Schwann cells were in being phagocytized in spite of myelin restitution. From 2 to 4 weeks, axonal regeneration and remyelination appeared at the same time a myelin disintegration and axonolysis. At 6 weeks, neural regeneration was similar to that of the contralateral control group. Conclusions: These results suggest that functional and histopathological changes, after injection of neurolytics into the peripheral nerves, are quite similar in both alcohol and phenol groups. The progression of functional and histopathological changes become more obvious according to the time interval following the injection. Consequently, side effects that develop following the use of alcohol or phenol may begin to improve around the time that nerve regeneration occurs, i.e., two to four weeks later.
실험연구 : 실험견에서 간혈류 차단 및 재관류 시 소량의 Nitroglycerin 투여에 의한 간혈류와 실시간 국소 간관류 및 산소 이용률의 변화
전재규 ( Jae Kyu Cheun ),정정길 ( Jung Kil Chung ),배정인 ( Jung In Rae ),김진모 ( Jin Mo Kim ),김애라 ( Ae Ra Kim ),장영호 ( Young Ho Jang ),안윤정 ( Youn Jeong An ),이용철 ( Yong Cheol Lee ) 대한마취과학회 2003 Korean Journal of Anesthesiology Vol.45 No.2
33권6호 영문부록 : Kainate에 기인된 신경독작용에 의한 백서 대뇌의 Polyamine 함량 변동에 대한 Propofol과 Nimodipine의 효과
이성룡(Seong Ryong Lee),전재규(Jae Kyu Cheun) 대한마취과학회 1997 영문부록 Vol.- No.-
서 론: Polyamine의 특정한 생리학적 기전이 잘 밝혀지지 않았지만 최근 많은 연구들을 통해 뇌의 여러 가지 병리학적 상태, 즉 간질발작, 전기적 자극, 허혈, 흥분성 독작용 조건등에서 polyamine의 함량이 현저히 변화하는 것으로 밝혀져 신경세포손상과 밀접한 연관이 있는 것으로 여겨지고 있다. 한편 propofol (2,6-diisopropylphenol)은 새로운 비barbiturate성 마취제로 신경마취에 널리 쓰이고 있으며 뇌보호작용에 대한 가능성에 대해 관심을 고취시키고 있다. 본 연구에서는 kainic acid투여에 의한 발작시의 polyamine함량변동에 대한 propofol의 영향을 nimodipine과 비교하여 보아 보호작용을 가늠하여 보고자 하였다. 방 법: Kainic acid (KA, 10mg/kg) 투여 3시간, 8시간, 및 24시간 후 cortex, hippocampus, 및 striatum을 분리하였고 propofol 및 nimodipine은 각각 25 mg/kg, 30 mg/kg로 투여하였다. Polyamine (putrescine; PU, spermidine; SD, spermine; SM)측정은 HPLC를 이용하였다. 결 과: KA투여 후 PU함량의 현저한 증가를 보이고 시간-의존적이며 이 양상은 propofol과 nimodipine에 의해 억제되었다. SD와 SM함량은 cortex와 hippocampus에서 다소 감소하였다. 이 SD및 SM 함량변동의 양상 역시 시간-의존적이며, propofol에 의해 다소 억제 되었다. 결 론: KA의 투여에 의한 경련발작시 백서 뇌의 polyamine 함량변동, 특히 PU의 변동을 통하여 볼 때, nimodipine과 함께 propofol이 신경보호작용을 가질 수 있으리라 추정된다. (Korean J Anesthesiol 1997; 33: S53∼S61)
실험연구 : 실험견에서 간혈류 차단 및 재관류 시 소량의 Nitroglycerin과 Dopamine 투여에 의한 신장 혈류 및 실시간 국소 신관류의 변화
한성욱 ( Seong Wook Han ),엄진원 ( Jin Won Uhm ),장영호 ( Young Ho Jang ),김애라 ( Ae Ra Kim ),김진모 ( Jin Mo Kim ),배정인 ( Jung In Bae ),정정길 ( Jung Kil Chung ),전재규 ( Jae Kyu Cheun ) 대한마취과학회 2003 Korean Journal of Anesthesiology Vol.44 No.6
척추마취후 발생하는 두통치료를 위한 Epidural Blood Patch 10 례 보고와 임상적 경험
전재규,정정길 대한마취과학회 1973 Korean Journal of Anesthesiology Vol.6 No.2
Autologous blood injected into the epidural space of 10 patients with a postlumbar puncture headache resulted in immediate and lasting cure except for one patient, due to technical failure to obtain proper identification for epidural injection. No serious complications were noticed in these cases except one who developed severe lower back pain radiating to the right leg immediately after epidural injection. A headache is the commonest untoward complication of spinal puncture. The clinical applications of many of the methods of treating post lumbar puncture headaches have been most unsatisfactory. This method of treating postspinal headaches, which has only been introduced recently, namely epidural blood patch, has resulted in immediate, satisfactory and permanent relief. It is to be noted that possible additional complications may be produced. therefore an absolute indication must be evaluated to avoid additional complications before the blood patch method is used. The amount of blood and the site of injection must be considered as an important factor to prevent post blood patch complications. The possible complications from autologous blood injections into th eepidural space are as follows: 1. Nerve root compression from epidural hematoma injected for blood patch. 2. Development of epidural hematoma by injuring venous plexus. Particularly dangerous secondary problems come from patients with purpura, scurvy, hemophilia, leukemia and anticoagulant therapy. 3. Tendency of epidural abscess caused by the blood being a good media for bacterial growth. 4. Localized back pain and lumbago. 5. Persistent headache aggravated by inadvertent subdural puncture. 6. Possibility of adhesive arachnoiditis.
이정구,정정길,전재규 啓明大學校 醫科大學 1991 계명의대학술지 Vol.10 No.4
Continuous epidural analgesia with intermittent morphine injection is a good technique for the management of intractable cancer pain. Since epidural tunnelling was introduced for the first time to our institution in 1988, it has been widely used for the cancer pain management. Recently epidural tunnelling was introduced for the keeping an inserted catheter for a long period of time. 25 patients with terminal cancer had been used an epidural tunnelling at the pain clinic of Dongsan Medical Center during the period of 3 months in 1991. Among the 25 patients, 14 were male and 11 were female, and most of them were at the ages of 6th decade. The causes of pain were from stomach cancer in 12, CBD cancer in 3, hepatoma in 2, pancreatic cancer in 2, uterine cervical cancer in 2, and miscellaneous cancer in 4 cases respectively. The outcome of treatment were excellent results in 14(56%), good in 9(36%), and moderate in 2 patients(8%). Accordingly satisfactory pain relief was achieved in 92% of the patients. It is suggested that this long-term management of intractable cancer pain by epidural bupivacaine and morphine with epidural tunnelling is satisfactory and reliable.
전재규,서인옥,배정인 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.2
25 Patients were received major spinal surgeries at main operating theater of Kangnam General Hospital from May 1990 to December 1990 by using the Haemonetics cell saver which was employed as an intraoperative blood salvage and autologous blood transfuser . The products of washed red blood cells were an average of 1490 cc packed RBC per case. Under the Light Microscopy, Washed RBC disclosed the morphologies of normal RBC size and shape. Fragmented RBCs or cell debris were not found and in one case agglutinated and denaturated RBCs were seen. While 20 patients were received spinal surgery prior to the untilization of cell saver, an average of 7.85 units of banked whole blood was transfused compared with 5.55 units in the cases of using the cell saver (p<0.05). Homologous banked blood utilization during spinal surgery declined more than 30% with the use of the cell saver. There was no evidence of infection, renal and/or hepatic failure related to the use of the cell saver. Haemonetics cell saver appeared to be safe, efficient and more over in some instanes life saving.
전재규,지대림,황정한 대한마취과학회 1992 Korean Journal of Anesthesiology Vol.25 No.6
Surgery and anesthesia-related ipsilateral reexpansion pulmonary edema has been seldom reported. The pathogenic mechanism of this rare complication is not clearly understood. A 23 year-old male had a decortication for left lung empyema under one-lung anesthesia. It took 6 hours to finish the scheduled operation. The patient came back to surgery again because of postoperative bleeding and he developed an ipsilateral pulmonary edema during the reexpansion of the collapsed lung. Fortunately, he was well tolerated with the developed edema which was resolved gradually without any specific management. The most likely mechanism is the increased pulmonary capillary permeability due to capillary injury resulting from hypoxia, oxygen free radicals, stretching, or surgieal manipulation. Secondly, the rise of the pulmonary capillary transmural pressure gradient and decreased lymphatic pump activity might also be involved as well.