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계절, 성에 따른 은행잎 중의 Ginkgolides 함량의 변화
성상현(Sang Hyun Sung),전순화(Soon Hwa Jeon),문영심(Young Shim Moon),이흠숙(Heum Sook Lee),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1994 약학회지 Vol.38 No.1
The contents of ginkgolides were determined in the leaves of male and female Ginkgo biloba from late spring until mid-autumn. Ginkgolides were detected during the whole growing season in the leaves of each tree. Ginkgolides content was low in late spring, gradually increased to reach a maximum in august and decreased thereafter. The male trees have two or three times higher ginkgolides content than the female trees. Comparing our results with that of previously reported values, the sexual variation of ginkgolides content seemed not to be genetic.
기내배양한 은행 유식물에서의 Ginkgolide의 생산
전미희(Mee Hee Jeon),성상현(Sang Hyun Sung),전순화(Soon Hwa Jeon),허훈(Hoon Huh),김영중(Young Choong Kim) 한국생약학회 1994 생약학회지 Vol.24 No.4
A platelet activating factor(PAF) antagonist ginkgolides produced from Ginkgo biloba are well known for their potential usage in septic shock and other PAF related diseases. Even though they are extracted from the leaves and on occasion the root bark, the exact biosynthetic site and pathway have not proved yet. In order to locate the enzymes involved and elucidate the biosynthetic site of the compounds, embryo-derived aseptic intact plantlet and plantlet without root have been cultured on 0.3% active carbon-containing solid Murashige and Skoog`s medium. The leaves from the six-week-old normal plantlet contained similar amount of ginkgolide B to that of outdoor plant leaves, while the plantlets without root had less than 30% of the ginkgolide B compared to the in vitro intact plantlets. The results suggest that the ginkgolides may be synthesized in the root and transported to the aerial part.