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- 저자 : 전계현(Kei Hyun Jeon) (검색결과 1 건)
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미성숙 마우스에 Bisphenol A 노출시 신경내분비계에서 에스트로겐 수용체 발현 및 신경행동 변화
성민제(Min Jae Seoung),신임철(Im Cheol Shin),이윷모(Yoot Mo Lee),손동주(Dong Ju Son),송연숙(Youn Sook Song),전계현(Kei Hyun Jeon),김윤배(Yun Bae Kim),이법준(Beum Jun Lee),김대중(Dae Joong Kim),윤영원(Young Won Yun),김태성(Tae Seong K 한국독성학회 2004 Toxicological Research Vol.20 No.3
A large number of chemical pollutants including phthalates, alkylphenolic compounds<br/> and organochlorine pesticides have the ability to disrupt endocrine function in animals, and alter cognitive<br/> function. Because hormone mediated events play an important role in central nervous system<br/> development and function, the changes in cognitive function seem to be mediated by the endocrinelike<br/> action of these chemicals. The present study therefore was designed to investigate effect of<br/> bisphenol A (BPA), an endocrine disrupting chemical on neuro-behavial patterns, and expression of<br/> estrogen receptors and tyrosine hydroxylase, a limiting enzyme of dopamine synthesis pathway. BPA<br/> was treated orally for 3 weeks into 3 week old mice, and then the neuro-behavial patterns (stereotype<br/> behaviors such as jumping rearing and forepaw tremor, climbing behavior, tail flick, rotarod and<br/> locomotor activity), and the expression of estrogen receptors and tyrosine hydroxylase were determined<br/> every 3 week for 9 weeks. During the treatment of BPA, the food uptake and body weight<br/> increase were not significantly changed. BPA resulted in the increased stereotype behaviors (jumping,<br/> rearing and forepaw tremor) 6 or 9 weeks after treatment. The time response to tail flick and<br/> locomotor activity were decreased by the treatment of BPA, whereas the time for rotarod was<br/> increased by the treatment of BPA. The expression of estrogen receptor alpha and beta was<br/> increased in the brain and pituitary gland. Maximum expression was found in the brain after 9 week<br/> of 100 mg/kg BPA treatment and in the pituitary gland after 6 week of 100 mg/kg BPA treatment.<br/> Tyrosine hydroxylase was increased in dose and time dependent manners in the brain but no change<br/> was found in the pituitary gland. The present data show that exposure of BPA in the young mice<br/> could alter expression of estrogen receptors and dopamine synthesis pathway, thereby modulate<br/> neuro-behavial patterns (increase of stereotype behaviors but decrease locomotor activity).
DBpia
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