특집 4 - 계란유통의 발전과 전망 - 계란유통의 발전과 향후 전망 -

이홍렬,Lee, Hong-Ryeol 대한양계협회 2009 월간 양계 Vol.41 No.11

제5우족지의 전이를 동반한 폐암

이홍렬 ( Hong Lyeol Lee ),김세규 ( Se Kyu Kim ),이환모 ( Hwan Mo Lee ),신동환 ( Dong Hwan Shin ),장중현 ( Jung Hyun Chang ),곽승민 ( Seung Min Kwak ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.1

선박의 폐열회수시스템 도입에 대한 실용성 연구

이홍렬(Lee Honghyel),이일오(Lee Ilo),이돈출(Lee Donchool) 한국마린엔지니어링학회 2012 한국마린엔지니어링학회 학술대회 논문집 Vol.2012 No.6

원저 : 원발성 종격동 종양 및 낭종에 대한 임상적 고찰 -344예에 대한 보고-

이홍렬 ( Hong Lyeol Lee ),김세규 ( Se Kyu Kim ),김해균 ( Hae Kyun Kim ),정경영 ( Kyung Young Chung ),이두연 ( Doo Yun Lee ),김성은 ( Sung Eun Kim ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.5

비소세포폐암에서 p53 종양억제 유전자와 K - ras 유전자의 돌연변이가 임상상에 미치는 영향

이홍렬(Hong Lyeol Lee),류정선(Jeong Seon Ryu),김주항(Joo Hang Kim),김성규(Sung Kyu Kim),이원영(Won Young Lee),이이형(Yi Hyung Lee) 대한내과학회 1998 대한내과학회지 Vol.55 No.5

N/A Objective: A multistep process of gene alterations is required for tumor formation, p53 gene mutation is the most frequent and K-ras gene mutation places second in the gene abnormalities of non-small cell lung cancer (NSCLC). The effect by the mutations of the p53 and ras genes on clinical manifestation is still highly controversial Little is known about the interaction between them in NSCLC. The present study was designed to investigate the effect by the mutations of the p53 tumor suppressor gene and K-ras oncogene on clinical manifestation, and the interaction between the mutations of two genes in the Korean NSCIC. Methods: Fifty-eight patients were enrolled in this study who had been diagnosed as having NSCLC from stage I to stage Ⅲ. They all had been alive for more than one month without any complication after curative resection. The paraffin-embedded lung tissues after resection were used to investigate the p53 expression by immunohistochemical staining, the mutations of the p53 and K-ras genes by polymerase chain reactionsingle strand conformation polymorphism(PCR-SSCP) and nucleotide sequencing. Results: p53 protein was overexpressed in 25.9% by immunohistochemical staining. Overexpression was significantly more frequent in epidermoid carcinoma(p=0.01634). But there was no significant difference between the overexpression group and the negative expression group according to stage and survival. By PCR-SSCP analysis, the mobility shift of the p53 gene was found in 29.1%. There was no significant difference between the groups with and without mobility shift according to cell type, stage and survival. By nucleotide sequencing, p53 gene mutation was 37.9%. The locations of mutation were dispersed among numerous codons and the modes of mutation were also diverse. There was also no significant difference between the groups with and without mutation according to cell type, stage and survival. K-ras gene mutation was 24.1% and only in codon 12 by nucleotide sequencing. Although there was no significant difference between the groups with and without mutation according to cell type or stage, K-ras gene mutation carried a significantly worse prognosis in NSCLC (overall survival p=0.0391, disease-free survival p=0.0318). When the patients were divided into 4 groups according to p53 gene mutation and K-ras gene mutation. there was also no significant difference among any group according to cell type or stage. The prognosis became worse if K-ras gene mutation accompanied(overall survival p=0.0021, disease-free survival p=0.0166). Only the stage(p=0.0313) and K-ras gene mutation(p=0.0457) were significant prognostic factors by Cox regression test. An analysis in stage III showed the significantly shorter survival period in the patients with K-ras gene mutation. K-ras gene mutation, therefore, was confirmed as the independently significant prognostic factor separately from stage. Conclusion: p53 gene mutation had no clinical or prognostic significance because of scattered locations and diverse modes of mutation in contrast to K-ras gene mutation, which had a significantly negative effect on the prognosis of NSCLC. p53 and K-ras gene mutations were apparently independent genetic alterations which played different roles in the clinical manifestation and prognosis of NSCLC.

폐외 악성 종양의 기관지내 전이

이홍렬(Hong Lyeol Lee),곽승민(Seung Min Kwak),장중현(Jung Hyun Chang),김세규(Se Kyu Kim),김성규(Sung Kyu Kim),이원영(Won Young Lee),신동환(Won Young Lee) 대한내과학회 1992 대한내과학회지 Vol.43 No.6

N/A Backgrounds: Endobronchial metastasis of extrapulmonary malignancies was defined as those cases in which metastatic foci were grossly evident in the main or lobar bronchi and occurs in less than 5% of all cases. The common extrapulmonary tumors associated with metastatic involvement of a central airway are carcinomas of the breast, kidney, colorectum and malignant melanoma. In the majority of cases, the primary tumor site is clinically apparent before symptoms of endobronchial metastasis. The clinical and roentgenographic features of endobronchial metastasis and primary bronchogenic carcinoma were found to be indistinguishable. Mostly, the histologic appearance of the bronchoscopic biopsy suggests the correct diagnosis but in some instances it may be impossible to differentiate metastatic involvement of the bronchus by an asymptomatic extrathoracic adenocarcinoma from a primary central adenocarcinoma of the lung. In addition to the treatment aspect of neoplasm spread, palliative surgical removal of endohronchial metastatic malignancies are strongly recommended to improve the patients qualify of life and to prevent resultant obstructive complications. Methods: We experienced 5cases of endobronchial metastasis during the recent 1½ years and reviewed the medical records of 12cases previously confirmed as endobronchial metastasis by bronchoscopic bioposies since 1985 to 1990. We investigated the clinical manifestations, primary sites, time intervals and bronchoscopic findings. Results: Breast carcinoma was the most common primary malignancy leading to the endobronchial metastasis. We also found the metastatic cases of hepatocellular carcinoma, sebacious gland adenocarcinoma and mouth floor carcinoma. Mostly patients complained of dyspnea and productive cough and chest X-ray revealed atelectasis. Endobronchial metastasis developed within 3 years in more than half of the cases and the mean time interval was 40,6months. In one prostate cancer and one thyroid cancer, metastasis was diagnosed prior to primary site presentation. On bronchoscopic examination, the right upper lobar bronchus was most commonly involved and subtotal obstruction was the most frequent finding. More than half of the patients expired within 2 years after the diagnosis of endobronchial metastasis. Conclusion: Endobronchial metastasis has unique clinical significance in that it requires differential diagnosis with primary bronchogenic carcinoma and aggressive palliative surgical management. If atypical clinical features are present or atypical cell type is discovered by biopsy of the lesion in lung ca, appropriate diagnostic studies should be undertaken to exlude the possibility of an asymptomatic extrapulmonary tumor before definite therapy is undertaken.

폐암의 진단에서 경기관지 침흡인술 ( TBNA ) 의 유용성에 대한 연구

이홍렬(Hong Lyeol Lee),김세규(Se Kyu Kim),장준(Joon Chang),김성규(Sung Kyu Kim),이원영(Won Young Lee) 대한내과학회 1995 대한내과학회지 Vol.48 No.2

N/A Objectives: Transbronchial needle aspiration (TBNA) is the newest technique to become available for use with the fiberoptic bronchoscope. But because it is associated with the technical difficulties and problems in the interpretation of cytologic examination, it carries the least application until now and its routine use just like forceps biopsy or washing is not recommended. Even though several indications have been suggested, the role of needle aspiration in the diagnosis of central lesion remains to be determined. The needle, however, would have the advantage of easy penetration through submucosal or peribronchial tissue layers that are difficult to access with biopsy forceps, it can have the unique diagnostic usefulness and it is a safe technique without any significant complications. The purpose of this study was to establish the diagnostic yield of TBNA, especially in patients with peribronchial or submucosal lesion or necrotic endobronchial lesion, to compare the yield to that of forcep biopsy. Methods: Sixty-seven patients who were found to have the lesions suggestive of peribronchial or submucosal tumor or necrotic endobronchial lesion during diagnostic fiberoptic bronchoscopy and fifty-two patients in whom primary or metastatic lung cancers were confirmed from January 1992 to December 1993 at Severance Hospital Yonsei University were included in this study. The TBNA always preceded all the other procedures in order to minimize the possibility of contamination of the aspirated specimen. Interpretation of TBNA result was done with four categories; ① carcinoma of definite cell type, ② carcinoma of uncertain cell type, ③ suspicious of malignancy, ④ negative or unsatisfactory, after correlating the biopsy result. Results: During this period, flexible fiberoptic bronchoscopic examination was done in 1,517 cases and TBNA in 4.4%. Of these patients of TBNA, 62.9% of lesions occurred in the right bronchi, 34.3% in the left bronchi, and 2.8% in the distal trachea. The difference of TRNA yield according to cell type or bronchoscopic appearance of lesion was not significant, but it showed the relatively better result in small cell carcinoma and metastatic lung cancer. The difference of the yield between TBNA and biopsy among any cell type or any bronchoscopic finding was not significant, but the difference between the yield of the biopsy alone and the biopsy combined with TBNA was statistically significant. The cases in which TBNA was the only diagnostic test that disclosed a malignant lesion were 15 (28.8%). For 5 patients in 10, repeated bronchoscopy could have been avoided if at initial bronchoscopy physicians had performed TBNA. Conclusion: Our findings suggest that TBNA is a safe technique that can significantly increase the diagnostic yield of fiberoptic bronchoscopy in the diagnosis of peribronchial or submucosal spread of bronchogenic carcinoma over that of forceps biopsy alone, and can be beneficial for suspected small cell carcinoma and pulmonary metastatic lesions. To obtain the maximal diagnostic yield, needle aspiration should be combined with the forceps biopsy.

원발성 폐암에 동반된 과칼슘혈증에 대한 임상적 고찰

이홍렬(Hong Lyeol Lee),박규은(Kyu Eun Park),김세규(Se Kyu Kim),장준(Joon Chang),김성규(Sung Kyu Kim),이원영(Won Young Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.6

N/A Objectives: The humoral hypercalcemia of malignancy(HHM) describes a very specific clinical syndrome due to the production of a peptide or family of peptide hormones which share sequence homology and functional homology with parathyroid hormone. Patients with HHM account for up to 80 percent of malignancy-associated hypercalcemia. The hypercalcemia in lung cancer is mainly mediated by parathyroid hormone-related protein. Typical patients with HHM had little or no skeletal involvement. Hypercalcemia is predominantly associated with epidermoid and large cell anaplastic carcinoma. From a clinical standpoint, patients with hypercalcemia are usually in advanced stages with obviously bulky tumors and, therefore, carry a poor prognosis. Methods: Between January 1987 and November 1993, the patients those who fulfilled the following criteria were chosen as a subjects in this study: ① corrected serum calcium >10.5mg/dl; ② histologically proven primary lung cancer; ③ symptoms which could possibly be attributed to hypercalcemia. We investigated the various clinical features that could characterize the hypercalcemia in lung cancer. Results: Thirty-one patients with lung cancer were hypercalcemic and most of them had squamous cell carcinoma in histologic finding. The incidence between 50 and 69 years of age was higher significantly. The occurrence of hypercalcemia showed a strong positive correlation with the degree of histologic differentiation and the advancement of cancer stage. And the mean serum calcium level also showed a strong positive correlation with the mass size and the performance scale. Some symtoms such as general weakness, anorexia, constipation, consciousness change, and weight loss were more frequent in the patients of higher calcium level. There was no significant difference in effectiveness among the therapeutic regimens for hypercalcemia. Most of patients were hypercalcemic at the time that the diagnosis of lung cancer was made. Most of them died within 1 month after the development of hypercalcemia. Conclusion: The hypercalcemia in lung cancer was found more frequently in men whose ages were between 50 and 69 years old, and in the patients who had poorly differentiated squamous cell carcinoma or the carcinoma in advanced stage. Mean serum calcium level was higher in more symptomatic patients, and in the patients with worse performance scale or larger tumor mass. The prognosis of hypercalcemic patients with lung cancer was extremely poor.

반복적 굴곡성 기관지경검사(RFB)의 유용성에 대한 연구

이홍렬 ( Hong Lyeol Lee ),문태훈 ( Tae Hoon Moon ),조재화 ( Jae Hwa Cho ),류정선 ( Jeong Seon Ryu ),곽승민 ( Seung Min Kwak ),조철호 ( Chul Ho Cho ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.48 No.3

경계를 침범한 건축에 대한 민법개정안 검토

이홍렬(Lee, Hong-Ryeol) 한국부동산법학회 2017 不動産法學 Vol.21 No.2

토지의 경계를 침범한 건축은 토지에 건축된 건물이나 돌출된 건물부분이 이웃 토지를 침범해서 건축된 경우를 의미한다. 법무부는 민법개정특별분과위원회를 설치하였고, 민법개정안을 2004년과 2013년에 입법예고한 바 있었다. 그 가운데 경계를 침범한 건축에 관한 법적 해결방안으로 제242조의2를 신설할 것을 제안하였다. 민법개정안은 입법적 결실로 이어지지 못해 타인의 토지경계를 침범한 건물의 철거여부를 둘러싼 분쟁은 아직도 지속되고 있으며, 이에 대한 입법적 해결방안은 민법에 명확히 규정되어 있지 않다. 판례의 주류적 태도는 경계침범건축물의 철거청구에 관한 법적 해결을 물권적 청구권의 일반적 원칙에 의하면서도 예외적으로 물권적 청구권의 행사가 문제된 사건에 있어서 구체적인 제반사정을 고려하여 신의칙에 반할 경우에 물권적 청구권의 행사를 제한한다. 본 글의 연구목적은 경계침범건축물의 철거청구와 관련해서 민법개정안의 법적 해결방안의 타당성 여부를 규명하고, 현행 우리 민법상 물권적 청구권의 행사는 상대방의 고의ㆍ과실을 요건으로 하지 않는 점과 배치되는 민법개정안의 문제점, 그 합리적 해결방안을 도출하고자 하는 것에 있다. Architecture invading boundary of land refers to structures or protruding parts of buildings invade neighboring land. In this situation, Ministry of Justice established the civil law revising special committee, and the Civil Law Amendment made by this committee was pre-announced in 2004 and 2013. The amendment suggested establishment of Article 242 Clause 2 about architecture invading boundary. However, the amendment couldn t be legislated, and there are still ongoing disputes whether buildings invading boundary of others land should be torn down. The legislative solution on this matter is not clearly defined yet. The Supreme Court adopts the legal solution about the claim of tearing down buildings invading boundary to the general principles of claim to repossess, but limits the exercise of claim to repossess by legal principles of right abuse by exceptionally considering specific circumstances in the cases that the excercise of claim to repossess became problems. The purpose of this study is to investigate the validity of legal solution by the Civil Law Amendment about the claim of tearing down buildings invading boundary, and to propose problems of the Civil Law Amendment that runs counter to the fact that the excercise of claim to repossess does not require the opposite party s intentionㆍnegligence in the current civil law of Korea, as well as logical solution for the matter.