아토피피부염 환자에서 유성 온천수를 이용한 온천욕의 보조적 치료 효과와 안전성에 대한 연구

이해을 ( Hae Eul Lee ),김형래 ( Hyeong Rae Kim ),임명 ( Myung Im ),이영 ( Young Lee ),김창덕 ( Chang Deok Kim ),이증훈 ( Jeung Hoon Lee ),서영준 ( Young Joon Seo ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.2

Background: Long-term use of various topical and systemic therapies for atopic dermatitis is associated with cutaneous and systemic adverse effects. Balneotherapy as an adjuvant treatment for atopic dermatitis has been extensively studied, and is considered effective and safe, in many countries. However, there is limited evidence from Korea, with only one previous report on the subject. Objective: The aim of this study was to investigate the therapeutic efficacy and safety of balneotherapy in the treatment of atopic dermatitis in a Korean population. Methods: Thirty atopic dermatitis patients were included in this randomized clinical trial evaluating the therapeutic efficacy of balneotherapy at Yuseong Spa, for four weeks. The patients were assigned to two groups: the control group (allowed treatment only) and balneotherapy group (additionally treated with balneotherapy). Assessment was made at baseline, and after 1, 2, and 4 weeks of treatment. Results: At week 4, compared with the control group, the balneotherapy group showed significantly greater improvement in the eczema area and severity index score, physician`s global assessment, patient`s self global assessment, and in the measured value of transepidermal water loss. The visual analog scale for pruritus in the balneotherapy group decreased, whereas it increased in the control group. None of the patients experienced any adverse events. Conclusion: Our study suggests that balneotherapy may be beneficial, is safe, and may increase the quality of life for patients with atopic dermatitis.

한국남자 대학생들의 여름철 피부색 변화에 관한 연구

이해을(Hae Eul Lee),조정구(Chung Koo Cho),이성낙(Sung Nack Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.2

This study was undertaken to clarify whether the color changes of skin in summer are remarkable or not. The skin color of abdomen, extensor and flexor of forearm, forehead, and cheek were measured in 27 health male students who had never tanned their skin intentionally during this experiment with Color and Color Difference Meter(Nippon Denshoku Kogyo Ca. CP6R 1001-DP) which represents skin color as 'L', 'a', and 'b' values. The 'L', 'a', and 'b' values mean the degree of lightness, redness, and yellowness respectively. Measurements had been performed four times repeatedly from summer(june) to auturmn(October) with intervals of 6 weeks. The obtained values were evaluated with statistical method, and the results were sumrnarized as follows: l. Abdominal skin showed no significant color changes in this experiment. 2 Extensor and flexor skin of forearm showed significant decrease in lightness from July, and the degree of decrease was more remarkable on extensor skin than on flexor skin. The lighteness had not been recovered by October on extensor skin and by September on flexor skin. There was no significant change in redness and yellowness on both places in this experiment. 3. Forehead skin showed no significant change in lightness and yellowness in this experiment, and showed transient decrease in redness in July. 4. Cheek skin showed no significant change in lighteness and redness in this experiment, and showed transient increase in yellowness in October.

Acinic Cell Tumor

이해을(Hae Eul Lee),방동식(Dong Sik Bang),이정복(Jung Bock Lee) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.2

Acinic cell tumor, a rare tumor of the salivary gland origin, consists of cells similar to the serous cells of the salivary gland. The tumor is almost exclusively paroti4 gland origin, accounting for 2. 7 to 4. 0% of all parotid tumors. The tumor is not ,benign but has at least a low-grade malignant potential. We described herein a case of acinic cell tumor which had occurred on an unusual site, right inner epicanthal area of a 9-year-old girl Microscopically, a hematoxylin-eosin stained biopsy specimen showed rnany lobules com of round or polyhedral tumor cells. Each tumor cell had distinct cell membrane, clear cytoplasm, and relative1y eccentric nucleus. The cytoplasm of tumor cell cantaine4 diastase resistant PAS-positive material.

Appendageal tumor, tumor of melanocyte, tumor of dermis and subcutaneous fat and cutaneous lymphoma

이해을 ( Hae Eul Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

1. Appendageal tumor 1) Follicular neoplasms ·Pilomatricoma: associated with activating mutations in β-catenin Multiple lesions → Gardner’s syndrome, myotonic dystrophy, Rubinstein-Taybi, Turner syndrome ·Proliferating trichilemmal tumor: derive from the outer root or trichilemmal sheath & present on the scalp of elderly individuals (female predominance) ·Birt-Hogg Dube syndrome: FLCN gene mutation (autosomal dominant) 2) Sebaceous neoplasms ·Nevus sebaceous: most commonly on scalp Development of secondary neoplasms → syringocystadenoma papilliferum, trichoblastoma, basal cell carcinoma Low risk of malignancy → treatment is primarily cosmetic ·Sebaceous adenoma & sebaceoma ·Muir-Torre syndrome: Germ-line mutation in the DNA mismatch repair genes, MSH2, MLH1, MSH6 (autosomal dominant) Sebaceous neoplasms (m/c:sebaceous adenoma), keratoacanthoma, internal malignancy(m/c: colon cancer) ·Sebaceous carcinoma: typically on the eyelids of elderly individuals 3) Eccrine neoplasms ·Syringoma (adult females), Chondroid syringoma (middle-aged and elderly males) ·Eccrine poroma: palms and soles of adults ·Nodular hidradenoma: scalp, face, trunk in middle-aged and elderly females 4) Apocrine neoplasms ·Hidradenoma papilliferum: small nodule on female vulva ·Syringocystadenoma papilliferum: present at birth or early childhood on scalp ·Cylindroma: usually on scalp in females 2. Tumor of melanocyte 1) Congenital nevomelanocytic nevi (CNN) ·Cranial or midline large CNN and large CNN with satellite lesions: increased risk of neurocutaneous/leptomeningeal involvement → MRI may be indicated 2) Spitz nevus: activating mutations of H-RAS 3) Dysplastic nevus 4) Malignant melanoma ·ABCD checklist: A(asymmetry), B(border irregularity), C(color variegation), D(diameter> 6mm, difference: “ugly duckling” sign), E(evolving over time) 3. Tumor of dermis and subcutaneous fat 1) Fibrous, fibrohistiocytic and histiocytic tumors 2) Vascular tumors ·Infantile hemangioma: expression of GLUT-1 Propranolol treatment → vasoconstriction, inhibition of angiogenesis, induction of apoptosis ·Kasabach-Merritt phenomenon: complication of tufted angioma and kaposiform hemangioendothelioma → tender, expanding vascular tumor with thrombocytopenia (usually severe) 3) Neoplasias and hyperplasias of muscular and neural origin 4) Neoplasms of subcutaneous fat 5) Kaposi’s sarcoma (KS): invariably linked with HHV-8 infection ·Classical KS: in old men, starts as localized form and progresses slowly 6) Angiosarcoma: highly malignant vascular tumor ·Primary angiosarcoma (elderly on head, neck, face) / Angiosarcoma in areas of chronic lymphedema / Postirradiation angiosarcoma 4. Cutaneous lymphoma 1) Cutaneous T-cell and NK-cell lymphomas ·Mycosis fungoides (MF) ·MF variants and subtypes (folliculotrophic MF, Pagetoid reticulosis, Granulomatous slack skin) ·Sezary syndrome ·Adult T-cell leukemia/lymphoma ·Primary cutaneous CD30-positive lymphoproliferative disorders (Primary cutaneous anaplstic large-cell lymphoma, Lymphomatoid papulosis) ·Subcutaneous panniculitis-like T-cell lymphoma ·Extra-nodal NK/T-cell lymphoma, nasal type ·Primary cutaneous peripheral T-cell lymphoma, unspecified (Primary cutaneous aggressive epidermotrophic CD8+ T-cell lymphoma, Cutaneous γ/δ T-cell lymphoma, Primary cutaneous CD4+ small or medium-sized pleomorphic T-cell lymphoma) 2) Cutaneous B-cell lymphomas ·Primary cutaneous marginal zone B-cell lymphoma ·Primary cutaneous follicle center lymphoma ·Primary cutaneous diffuse large B-cell lymphoma, leg type ·Primary cutaneous diffuse large B-cell lymphoma, other ·Precursor hematologic neoplasm ·CD4+/CD56+ hematodermic neoplasm (blastic NK-cell lymphoma)

건선에 대한 경구용 Etretinate ( Ro 10 - 9359 ) 및 Vitamin E의 병용치료 효과

이성낙 ( Sung Nack Lee ),이정복 ( Jung Bock Lee ),조정구 ( Chung Koo Cho ),이해을 ( Hae Eul Lee ),김수찬 ( Soo Chan Kim ),김덕현 ( Duck Hyun Kim ),방동식 ( Dong Sik Bang ),이승헌 ( Seung Hun Lee ),박한성 ( Han Sung Park ),국홍일 ( 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.2

Etretinate(Ro 10-9359), an aromatic analogue of vitamin A acid, has been known to be effective in the treatment of psoriasis, Darier's disease, pityriasis rubra pilaris, ichthyosis, and palmoplantar keratoderma when administered orally. In this experiment, we compared the therapeutic and side effects between a group with high dose therapy(initially 75mg of etretinate a day) and an another group with low dose therapy(initially 40mg of etretinate a day). We also observed whether the pretreatment followed by combined treatment with vitamin E could potentiate the therapeutic effect as well as reduce the side effects of oral etretinate. This experiment comprised 102 moderate to severe psoriatic patients. The following results were obtained from this experiment. 1. Fifty-six among 92 patients(61%) who were treated with etretinate for more than 4 weeks showed good to excellent therapeutic effect. 2 The high dose therapy was more effective, but showed more side effects than low dose therapy. 3 Vitamin E did not potentiate the effect of etretinate. In low dose therapy, the pretreatment followed by combined treatment with vitamin E showed a tendency to reduce the side effects of etretinate.

과호산구 증후군 환자에서 발생한 선상 편평 태선

박승배 ( Seung Bae Park ),이해을 ( Hae Eul Lee ),임명 ( Myung Im ),이영 ( Young Lee ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.7

Hypereosinophilic syndrome (HES) is characterized by chronically increased peripheral blood eosinophil levels and organ damages related to eosinophilic infiltration. Cutaneous manifestations are common (>50%) and non-specific. It is generally manifested as erythematous pruritic eczema. Linear lichen planus has not been reported in HES. A 35-year-old woman was presented with linear brownish papules and plaques on her left arm. She had been diagnosed with HES three years earlier. Initially, the skin lesions were manifested as linear pruritic erythematous plaques, but they gradually transformed into shiny brownish plaques. Skin biopsy specimens showed irregular acanthosis of the epidermis and band-like infiltrations of lymphocytes and eosinophils with necrotic keratinocytes in the papillary dermis. We proposed that the eosinophil infiltration was caused by HES, and that the patient`s histological and clinical manifestations should account for linear lichen planus. (Korean J Dermatol 2013;51(7): 552∼555)

Eccrine Spiradenoma

박윤성(Yoon Sung Park),이해을(Hae Eul Lee),방동식(Dong Sik Bang) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.4

Eccrine spiradenoma is clinically characterized by a solitary, movable, tender noduie occurring most frequently on the ventral surfase of the upper body. A striking symptom is paroxysmal pain. Histopathologically, the encapsulated lobules of the tumor are composed of masses of basophilic cells, usually arranged in whorls, cords, and pseudogland.s. Within the whorls and pseudoglands, two types of celIs are notedperipheral intensely staining cells and central pale-staining cells. We describe herein a patient with an indolent eccrine spiradenoma, which had been diagnosed histopathologically.

젊은 여성 피부색의 부위별 차이 및 계절적 변화에 관한 연구

이성낙(Sung Nack Lee),박윤성(Yoon Sung Park),이해을(Hae Eul Lee),조정구(Chung Koo Cho) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.2

Sixty-five volunteers whose skin had never been tanned intentionally participated in this experiment. The skin colors of extensor and flexor of forearm, fore- head, and cheek were measured with Color and Color Difference Meter(Nippon Denshoku Kogyo Co. CP6R 1001-DP) which represents .kin color as 'L, a, and b in values. The L, a', and b values mean the degree of ligntness, redness, and yellowness respectively. Measurement has been performed seven times repeatedly in a year at regular intervals. From the study, the following results were obtained. ]'lexor skin of forearm showed the highest lightness in a year compared to the other regions. All of the regions examined showed the highest lightness in spring compared to the other seasons. 3. Cheek skin showed the highest redness among the four checked regions in a year. 4, All of the checked regions showed the higher redness in summer than in spring. and autumn. 5 All of the checked regions showed the lowest yellowness in May.

화상 반흔에서 유래된 사마귀양 암종 ( Verrucous Carcinoma )

방동식(Dong Sik Bang),김형일(Hyung Il Kim),이해을(Hae Eul Lee),황규광(Kyu Kwang Hwang) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6

Verrucous czrcinoma is a well accepted clinicopathologic entity that is a lowgrade variant of squamous cell carcinoma. This tumor develops typically in moist areas which are frequent site of chronic inflammation. We herein report a case of verrucous carcinoma developed in a burn scar on. the posterolateral aspect of left popliteal fossa.

Benign Cephalic Histiocytosis

김덕현(Duck Hyun Kim),방동식(Dong Sik Bang),한신원(Shin Won Han),황규천(Kyoo Cheon Whang),이해을(Hae Eul Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3

A 18-month-old girl was seen because of an yellowish brown papular eruptions on the face, earlobes and neck of one year duration. A skin biopsy specimen revealed circumscribed cellular infiltrates composed of predorninantly pleornorphic histiocytes. Electron microscopy of biopsy material disclosed numerous worm like particles and coated vescles in limited area of the cell cytoplasm, consistent with the findinga described in benign cephalic histiocytosis. After six months of her first visit, the individual papules became flattened.