http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cu2+ 와 H2O2 에 의한 Collagen 변성에 있어서 Rutin 과 Quercetin 의 보호작용
박재완,신용규,이정수 ( Jae Wan Park,Yong Kyoo Shin,Chung Soo Lee ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.2
Flavonoids are suggested to possess both anti-oxidant and chelating ability. Effects of rutin and quercetin on the degradation of collagen and depolymerization of hyaluronic acid by Cu^(2+) and H₂O₂ were investigated. Cu^(2+) plus H₂O₂-induced collagen degradation was prevented by the oxygen radical scavengers SOD, catalase, DMSO and DABCO and by the metal chelators EDTA and penicillamine. Rutin and quercetin markedly prevented collagen degradation by Cu^(2+) plus H₂O₂. The decrease of viscosity of hyaluronic acid by H₂O₂ was restored by rutin but not by quercetin. Rutin and quercetin decomposed H₂O₂. These results suggest that rutin and quercetin may prevent the damages of collagen and hyaluronic acid by Cu^(2+) and H₂O₂ by their scavenging action on oxygen radicals and chelating action on Cu^(2+).