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이영규 ( Yeong Kyu Lee ),구본석 ( Bon Seok Ku ),김영훈 ( Young Hun Kim ),이채욱 ( Chae Wook Lee ),김기호 ( Ki Ho Kim ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.5
Pseudocyst of the auricle is an uncommon condition, which typically presents as an asymptomatic, noninflammatory swelling of the external ear. Most of the patients are usually young, healthy males without trauma. Histological examination is characterized by the intracartilaginous accumulation of serous fluid without an epithelial lining. The pathogenesis is unknown. Some theories about the release of lysosomal enzymes or inflammatory mediators and embryologic dysplasia of the auricle cartilage have been suggested. Treatment of pseudocyst of the auricle has usually involved a simple aspiration and compressive dressing, but this may often cause the fluid to reaccumulate. Treatment by surgical excision may result in a permanent deformity and scar of the auricle. Therefore, various treatments have been suggested. We report a case of pseudocyst of the auricle successfully treated by incisional biopsy only. (Korean J Dermatol 2007;45(5):518~520)
저용량의 Cyclosporine으로 치료한 전신성 광택태선
이영규 ( Yeong Kyu Lee ),최규원 ( Kyu Won Choi ),김영훈 ( Young Hun Kim ),이채욱 ( Chae Wook Lee ),김기호 ( Ki Ho Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12
Lichen nitidus is a rare and chronic inflammatory dermatosis first described by Pinkus in 1907. The etiology of it is still unknown and the majority of instances appear in children and young adults. The lesions are usually asymptomatic but may be mildly pruritic and the Koebner phenomenon may be observed. It is characterized by flesh-colored, minute, shiny papules occurring on the genitalia, abdomen, chest, and extremities. This disorder is most often localized, but there are rare reports of patients having a more generalized distribution of lesions. Although lichen nitidus is self-limited in most cases without any sequelae, the course of generalized lichen nitidus is unpredictable. We report a case of a 16-year-old girl diagnosed by generalized lichen nitidus refractory to general treatment and successfully treated with low dose cyclosporine (2 mg/kg/day). (Korean J Dermatol 2007;45(12): 1311∼1314)
TTA법을 이용한 색소 질환에서 티로시나제의 발현 양상
이영규 ( Yeong Kyu Lee ),김영훈 ( Young Hun Kim ),김기호 ( Ki Ho Kim ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.3
Background: Tyrosinase is the critical enzyme in melanin synthesis. DOPA staining has been used as a standard assay for detecting tyrosinase activity, but it exhibits several limitations. Tyramide based tyrosinase assay (TTA) is a simple and sensitive tyrosinase detecting method. Objective: This study aimed to compare the stainability of pigmentary disorders using TTA and DOPA staining. Methods: The subjects were composed of hyperpigmentary disorders (n=10), hypopigmentary disorders (n=7), and alopecia areata (n=7). The colocalization study of TTA and Mitf using immunofluorescence was performed on alopecia areata. DOPA staining was performed on all tissues to compare with TTA immunohistochemistry. Results: TTA positive cells were correlated with Mitf positive cells in the tissue of alopecia areata. In hyperpigmentary disoders, TTA was stronger than DOPA staining. TTA and DOPA staining didn`t observe the positive cells in lesion of vitiligo and piebaldism, but both showed the positive cells in normal skin. TTA staining showed positive cells in the transitional lesion of vitiligo but, DOPA staining did not. In alopecia areata, TTA positive cells were observed, but DOPA staining did not. Conclusion: TTA is more sensitive than DOPA staining in pigmentary disorders for detecting tyrosinase activity. (Korean J Dermatol 2008;46(3):325∼333)
고용량의 전신 스테로이드 정맥 주사 후 소장 천공이 동반한 Churg-Strauss 증후군
이영규 ( Yeong Kyu Lee ),최규원 ( Kyu Won Choi ),이채영 ( Chae Young Lee ),김홍석 ( Hong Seok Kim ),김기호 ( Ki Ho Kim ),김영훈 ( Young Hun Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.7
Churg-Strauss syndrome is an uncommon disorder characterized by bronchial asthma or allergic rhinitis, peripheral eosinophilia, systemic necrotizing vasculitis, and extravascular granuloma formation. It commonly affects the lungs, skin, gastrointestinal tract, peripheral nerve, kidneys and the heart. Gastrointestinal symptoms of Churg-Strauss syndrome are common, mainly shown in abdominal pain, diarrhea, or bleeding. Ulceration, perforation, stenosis can occurr with ischemia induced by vasculitis. Gastrointestinal perforation by Churg-Strauss syndrome has been reported rarely, and was recently discovered to have a close correlation to systemic steroid treatment. Nearly one third of patients infected with a gastrointestinal perforation die. This report covers the interesting case of a 54 year-old woman who was being treated for asthma, and was diagnosed as Churg-Strauss syndrome by multiple polyneuropathy and ulcerative macules. Small intestine perforation was generated 4 days after high dose systemic steroid intravenous injection. (Korean J Dermatol 2008;46(7):950~954)
이영규 ( Yeong Kyu Lee ),구본석 ( Bon Seok Ku ),김영훈 ( Young Hun Kim ),이채욱 ( Chae Wook Lee ),김기호 ( Ki Ho Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.4
Pigmented neurofibroma is a rare cutaneous tumor accounting for less than 1% of all neurofibroma. It is characterized histologically by the coexistence of scattered melanin-laden cells and benign spindle cells with neural differentiation. The origin of these tumors are unknown, and they show a storifom pattern. In our case, the patient had giant cafe au lait patches on the left trunk which had been present since birth, freckles on both axilla, and two dark-red colored plaques which had appeared 2 years ago. Histologic examination revealed pigmented neurofibromas showing the melanin-laden, pigmented cells within the upper dermis and plexiform neurofibromas in the subcutaneous tissue. We describe a case of pigmented neurofbroma in a 13-year-old male patient. (Korean J Dermatol 2007;45(4):387~390)
최규원 ( Kyu Won Choi ),이채영 ( Chae Young Lee ),이영규 ( Yeong Kyu Lee ),김홍석 ( Hong Seok Kim ),이채욱 ( Chae Wook Lee ),김기호 ( Ki Ho Kim ),김영훈 ( Young Hun Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.6
Xanthoma disseminatum (XD) is a rare, potentially progressive non-Langerhans cell histiocytosis, which preferentially affects males in their childhood or young adulthood. It is characterized by the insidious onset of small, yellowish-red to brown papules and nodules that are discrete and disseminated. They characteristically involve the eyelids and flexural areas of the axillary and inguinal folds, and the antecubital and popliteal fossae. Systemic disease frequently occurs, the most common manifestation being diabetes insipidus (DI), which occurs in about 40% of cases and is due to deposition of xanthoma cells in the hypothalamic-pituitary axis. We present a case of XD with DI, which was treated with the combination therapy of CO2 laser vaporization, cyclophosphamide, electrocauterization and synthetic anti-diuretic hormone. (Korean J Dermatol 2008;46(6):826∼830)
건선환자의 말초혈액내 Tc2 세포 및 CCR4의 발현과 PASI Score와의 연관성
이기열 ( Ki Yeol Lee ),이영규 ( Yeong Kyu Lee ),김경희 ( Kyeong Hee Kim ),김기호 ( Ki Ho Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.11
Background: Psoriasis is a chronic relapsing skin disorder that is characterized by abnormal epidermal proliferation, inflammation and angiogenesis. It causes emotional and social consequences that go far beyond the skin; therefore, many methods to measure and monitor the severity of psoriasis have been reported. Objective: This study aims to evaluate the usability of the flow cytometric analysis of the T cell subsets and their chemokine receptors in the peripheral blood of the psoriasis patients as a severity index. Methods: The T cell subsets and their chemokine receptor expression (CXCR3, CCR4) in the circulating blood of thirty psoriasis patients (PASI score: 2.2∼44.2) and twenty healthy controls were examined by flow cytometry. The relationship between the PASI score and the T cell subsets/chemokine receptors was also analyzed. Results: The patients showed significantly higher number of Tc1 (CD8+CXCR3+), Tc2 (CD8+CCR4+) and CXCR3/CCR4 expressing cells than did the control group. Especially, the moderate to severe patients (a PASI score greater that 5) showed a higher number of Tc1, Tc2 and CCR4 expressing cells than did the control group. In the severe patients (a PASI score greater than 10), the frequency of circulating Tc2 cells and CCR4 expressing cells was directly correlated with the PASI score. Conclusion: Our findings suggest that flow cytometric analysis of the circulating T cell subsets with further classification could serve as an indicator of the disease severity in psoriasis patients. (Korean J Dermatol 2010;48(11):919∼924)