후두 결핵의 후두 내시경 소견과 임상 양상 분석

이상혁,이승석,이노희,반재호,이경철,진성민,Lee, Sang-Hyuk,Lee, Seung-Suk,Lee, No-Hee,Ban, Jae-Ho,Lee, Kyung-Chul,Jin, Sung-Min 대한후두음성언어의학회 2006 대한후두음성언어의학회지 Vol.17 No.1

Background and Objectives: There has been a gradual decline in the incidence of laryngeal tuberculosis due to effective an-tituberculous chemotherapy and improvement in the standard of living. During the last decade, however, the disease has changed its clinical pattern. We aimed to study a clinical and telescopic evaluation of laryngeal tuberculosis. Materials and Method: A retrospective clinical analysis was done for 16 patients who diagnosed laryngeal tuberculosis from January 2000 through December 2004. All patients had a complete clinical and laboratory work-up including telescopy, chest X-rays, sputum cultures, Tbc PCR(polymerase chain reaction). Laryngeal biopsies were performed in some cases. All the patients received proper antituberculous chemotherapy. Results: The patients age ranged from 21 to 59 with a mean age 43. The male to female ratio was 10:6. The prominent presenting symptom was hoarseness. The various telescopic findings were categorized: 7 patients showed ulcerative, 4 patients granulomatous, 3 patients ulcerofungative, 2 patients had nonspecific inflammatory lesions. Involving sites were true vocal cord most commonly in 12 patients. Three of 16 patients had normal chest X-ray fmding. Among 16 patients, 4 patients showed positive response for AFB stain, 13 patients showed positive for Tbc PCR. Biopsy was done for 3 patients who were not confirmed in initial tuberculous test. All patients responded satisfactorily to antituberculous medication. Conclusion: The telescopic findings and clinical manifestations of laryngeal tuberculosis have changed and seemed to be different from those of classic reports. Thus, the clinicians who deal with the various symptoms and diseases should be aware of the existence of laryngeal tuberculosis and the changing patterns of the disease.

포커스 - 국내 농산물 안전성 수준 어떠한가?

이상혁,Lee, Sang-Hyeok 한국작물보호협회 2015 자연과 농업 Vol.310 No.-

가스터빈 연소진동 데이터 처리를 위한 FFT 기반의 모니터링 시스템

이상혁,강필순,Lee, Sang-Hyeok,Kang, Feel-Soon 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.12

This paper presents a method for improvement of communication speed and reduction of data storage space in gas turbine monitoring system to acquire, save, and display combustion vibration data. The proposed method implements FFT from sampled raw data. The FFT result data are encoded to be transferred to monitoring PC for storage. By this way, it can reduce data storage space. To display the received data, it needs inverse FFT to reconstruct original signal. To verify the validity and efficiency of the proposed scheme, computer-aided simulation are carried out. It includes the analyzed results the relationship between FFT's order and Gibb's Phenomenon. Finally, high-performance of the proposed method is proved by combustion experiment results using a prototype gas turbine. 본 논문에서는 가스터빈의 연소진동 데이터의 취득, 저장, 표시를 위한 모니터링 시스템의 구현에 있어 통신 속도의 향상 및 데이터 저장 공간을 축소시킬 수 있는 방안을 제시한다. 제안된 방법은 샘플 원시 데이터(Raw Data)로 부터 FFT를 수행하고 결과 데이터를 코드화 하여 모니터링 PC로 전송하여 저장함으로서 데이터 저장 공간을 줄일 수 있다. 수신된 데이터를 화면에 표시하기 위한 원신호로의 복원은 역 FFT에 의해 이루어진다. 제안된 방식의 타당성과 효율성 검증을 위해 시뮬레이션을 수행하였으며, FFT 차수와 Gibbs's 효과간의 상관관계를 분석하였다. 모의 가스터빈의 연소실험을 통해 제안된 데이터 처리 및 저장 방법의 우수성을 검증하였다.

보간법을 이용한 효율적인 모니터링 시스템 구성

이상혁,강필순,Lee, Sang-Hyeok,Kang, Feel-Soon 한국정보통신학회 2008 한국정보통신학회논문지 Vol.12 No.2

본 논문에서는 모니터링 시스템의 데이터 취득과 처리 과정에 있어 데이터를 효율적으로 저장, 복원시킬 수 있는 방법을 제시한다. 타겟 시스템에서 취득된 원시 데이터로부터 보간법을 기반으로 최소의 데이터를 추출한다. 이는 TCP/IP 통신에 의해 모니터링 PC로 전송되어 저장되며, 보간법을 통해 다시 원 신호로 복원된다. 따라서 통신 패킷양이 저감되어 데이터 통신 속도가 향상되며, 데이터 저장 공간을 줄일 수 있어 장시간에 걸쳐 취득되는 데이터를 효율적으로 관리할 수 있는 모니터링 시스템 설계가 가능하다. 제안된 데이터 취득과 복원 알고리즘은 큐빅 헤르미트 보간법에 기반을 둔다. 데이터 처리 방법의 타당성을 검증하기 위해 시뮬레이션 결과를 제시하며, 타 보간법 적용에 의한 결과와 비교하여 우수성을 검증한다. 계통연계형 태양광 발전 인버터의 모니터링 시스템에 적용하여 제안된 방식의 효율성을 실험적으로 검증한다. This paper presents an efficient data storage and reconstruction method in data acquisition and processing of monitoring system. The proposed method extracts minimum data using an interpolation from raw data which are acquired from a target system. They are transferred and saved in a monitoring PC via TCP/IP communication, and then reconstructed as original signals. Therefore, it is possible to design an efficient monitoring system by the improved data communication speed due to the reduced communication packet, and it reduces the storage space. The algorithm for data acquisition and reconstruction is based on Cubic Hermite interpolation. To verify the validity of the proposed scheme, we presents simulation results compared with other interpolation based approaches. Finally, it is applied to a monitoring system for grid-connected photovoltaic power generation system to prove the high-performance of the proposed method.

보툴리눔 독소의 약리

이상혁,이현섭,진성민,Lee, Sang Hyuk,Lee, Hyun Sub,Jin, Sung Min 대한후두음성언어의학회 2012 대한후두음성언어의학회지 Vol.23 No.2

Botulinum toxins are the most potent toxins known to mankind. Botulinum toxin acts by blocking the cholinergic neuromuscular or the cholinergic autonomic innervation of exocrine glands and smooth muscles. Seven distinct antigenic botulinum toxins (A, B, C, D, E, F and G) produced by different strains of Clostridium botulinum have been described and only A and B type of botulinum toxins were clinically used. Toxins were consisted of a heavy chain with a molecular weight of 100 kD and a light chain with a molecular weight of 50 kD. Toxins are bound with an astounding selectivity to glycoprotein structures located on the cholinergic nerve terminal. Subsequently light chain of toxin is internalized and cleaves different proteins of the acetylcholine transport protein cascade transporting the acetylcholine vesicle from the intracellular space into the synaptic cleft. After a decade of therapeutic application of the toxin, no anaphylaxis or deaths have been reported and systemic adverse effects have not been reported so far. However the toxin's immunologic properties can lead to the stimulation of antibody production, potentially rendering further treatments ineffective. Botulinum toxin is a safe and effective treatment. Use of botulinum toxin in clinical medicine has grown exponentially in recent years, and many parts of the human body are now being targeted for therapeutic purposes.

21세기 보병전투차량(IFV/ICV)의 발전 방향

이상혁,Lee, Sang-Hyeok 한국방위산업진흥회 1999 國防과 技術 Vol.- No.241

현대전은 군수면에서의 기술적 우세에 의해 전쟁의 승패가 결정된다는 걸프전의 교훈을 바탕으로, 주요 선진국들은 나름대로의 계획과 형편에 따라 주변기술의 발전과 더불어 21세기를 대비하는 보병전투차량의 연구.개발을 수행하고 있다. 이러한 주요 선진국들의 IFV/ICV의 발전 추세를 철저하게 분석하여, 우리 군의 현 실태와 앞으로의 나아갈 바를 판단할 수 있는 계기를 마련하고, 이에 적극적으로 대처하는 연구.개발 활동과 접근자세가 내부적으로 더욱 필요하다고 판단된다

양성 성대 병변의 비수술적 치료

이상혁,Lee, Sang Hyuk 대한후두음성언어의학회 2015 대한후두음성언어의학회지 Vol.26 No.2

Benign vocal fold lesions, such as vocal nodules, polyps and Reinke's edema, usually result from chronic voice overuse. Conservative management such as voice therapy and pharmacotherapy are used as the primary treatment techniques. The main purpose of voice therapy is to identify and reduce voice misuse to achieve the optimal voice. But complete resolution may not be possible in all patients after voice therapy. Furthermore, some patients with voice-related occupations, voice rest and voice therapy are sometimes difficult, which makes it hard to carry out the treatment. When conservative therapy is ineffective, laryngeal microsurgery can be performed under general anesthesia. However, potential complications following laryngeal suspension and violation of the layered structure of the vocal fold during surgery should be considered before surgery. In recent decades, emerging literatures have demonstrated the potential usefulness of vocal fold steroid injection as an alternative treatment option for benign vocal fold lesions. The most advantageous feature of vocal fold steroid injection is the maintenance of regional anti-inflammatory effects while preventing the potential systemic adverse effects of the steroid. Many non-surgical treatment methods can be conducted using different approaches in the office setting. It can be applied as an alternative treatment modality for the management of various benign vocal fold lesions.

공황장애 약물 치료에 대한 한국형 알고리듬 개발(3) - 인지행동치료 -

이상혁,양종철,윤세창,서호석,김찬형,유범희,김민숙,Lee, Sang-Hyuk,Yang, Jong-Chul,Yoon, Se-Chang,Suh, Ho-Suk,Kim, Chan-Hyung,Yu, Bum-Hee,Park, Min-Sook 대한불안의학회 2008 대한불안의학회지 Vol.4 No.1

Objective : A working group of psychiatrists from the Korean Academy of Anxiety Disorders was established to determine the appropriate medication algorithm for treating patients with panic disorder. In this article, we discussed the consensus among psychiatrists regarding the use of cognitive behavior therapy (CBT) in the development of a treatment algorithm for panic disorder in Korea. Methods : Based on the guidelines or algorithms published by the American Psychiatric Association, National Institute for Clinical Excellence, and Canadian Psychiatric Association, we constructed questionnaires regarding the core components and contents of CBT for patients with panic disorder. Fifty-four experts in panic disorder completed the questionnaires. Results : There was statistically significant consensus among the experts in the belief that cognitive reconstruction and psychological education are the core components of CBT for the treatment of patients with panic disorder. However, there was some inconsistency between the opinions of some experts regarding the content and frequency of CBT and the results of studies published outside of Korea. Conclusions : CBT, especially the psychological education and cognitive reconstruction components, should be considered when treating patients with panic disorder. However, further consideration needs to be put into the design of a more detailed treatment guideline for the use of CBT in the treatment of patients with panic disorder.

상완골 골절에 동반된 요골 신경 마비 환자에서 초음파 검사의 유용성 - 술기 보고 -

이상혁,성창민,박형빈,Lee, Sang-Hyuk,Sung, Chang-Min,Park, Hyung-Bin 대한정형외과초음파학회 2012 대한정형외과 초음파학회지 Vol.5 No.1

상완골 골절에 동반된 요골 신경 마비는 전체 상완골 골절의 약 10%에서 발생하는 것으로 보고되고 있으며, 상완골 골절 수술과 관련하여 발생하는 의인성 요골 신경 마비는 10~20%로 알려져 있어 임상에서 흔히 경험하게 된다. 상완골 골절에 동반된 원발성 요골 신경 마비나 의인성 요골 신경 마비가 발생한 경우 요골 신경이 단열된 것인지 아니면 주위 구조물에 압박된 것인지 등의 요골 신경의 해부학적 상태의 평가는 자연회복을 기다릴 것인지 아니면 수술적 탐색술을 실시할 것인지 여부를 결정하는데 중요하다. 저자들은 상완골 골절에 동반된 원발성 요골 신경 마비 1예와 수술과 관련한 의인성 요골 신경 마비 1예를 초음파 검사로 신경의 해부학적 상태를 확인한 후 신경의 단열이 있었던 1예는 비복신경 이식술을 시행하였고, 신경유착이 있었던 1예는 신경박리술을 시행하여 만족할 만한 임상결과를 얻었기에 초음파를 이용한 요골 신경 검사를 중심으로 문헌 고찰과 함께 보고하고자 한다. Primary radial nerve palsy occurs in association with approximately 10% of humerus shaft fractures. Secondary radial nerve palsy, which is iatrogenic, occurs in association with approximately 10% to 20% of humerus shaft fractures. Whether the radial nerve palsy is caused primarily by the fracture or secondarily by the surgery, it is necessary to determine whether the radial nerve is being disrupted or compressed by the surrounding structures. This evaluation will dictate whether to await natural recovery or to perform surgical exploration. The current authors report one case of primary radial nerve palsy, due to the humerus fracture, and one case of secondary radial nerve palsy, associated with the osteosynthesis procedure. In both patients, the radial nerve was assessed for anatomical integrity with ultrasonography. Nerve disruption was found in one patient, and a sural nerve graft was performed. Nerve adhesion was found in the other patient, and neurolysis was performed. In both cases, the clinical results were satisfactory. This report focuses on the usefulness of ultrasonography in radial nerve assessment in patients with radial nerve palsy.

후두 내시경의 진단적 역할

이상혁,Lee, Sang-Hyuk 대한후두음성언어의학회 2010 대한후두음성언어의학회지 Vol.21 No.1

Diagnosis of a patient with dysphonia begins with a thorough history and physical examination. Larynx can be visualized either indirectly or directly with a rigid or flexible laryngoscope. One notable limitation of simple indirect laryngoscopy is that the examination dose not yields a recordable and reproducible image of the larynx and vocal tract. And unaided human eye is unable to visualize the vibratory patterns of the true vocal cord during phonantion. When available, stroboscopy provides useful information regarding vocal told closure, vibration, and mucosal wave which is useful to decide between microsurgery, vocal reeducation or a combined treatment Even there are some limitations, recognition of the advantages and disadvantages of stroboscopy allows for optimal appreciation and stroboscopy remains an essential diagnostic tool in the assessment of dysphonia.