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오갑진(Kap Jin Oh),최윤석(Yun Seuk Choi),최일식(Il Shik Choi),박시경(Si Kyung Park),이규흥(Kyou Heung Lee),정순간(Sun Gan Chung),조의환(Eui Hwna Cho) 대한약학회 1992 약학회지 Vol.36 No.5
Astilbes rhizoma has been used for headache, arthralgia, chronic bronchitis and stomachalgia in traditional chinese medicine. The analgesic activities and their components of Astilbe chinensis var. davidii Rhizomes were evaluated. The ether and ethylacetate fractions of 70% EtOH extract showed considerable analgesic activities by acetic acid induced writhing method. Compound 1~5 were isolated from ethylacetate fraction and identified as gallic acid, (+)-catechin, (+)-gallocatechin, bergenin and 11-O-galloylbergenin on the basis of spectroscopic methods. Among them (+)-gallocatechin showed stronger analgesic activity than that of other compounds.