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Erythropoietin(EPO)에 대한 변이원성시험
제정환(Jeong-Hwan Che),이광훈(Guang-Xun Lu),박진성(Jin-Sung Park),윤준원(Jun-Won Yun),김태원(Tae-Won Kim),김형섭(Hyung-Sub Kim),박지은(Jie-eun Park),윤신근(Sin-Keun Youn),이영순(Yong-Soon Lee) 한국독성학회 1999 Toxicological Research Vol.15 No.3
In order to evaluate the mutagenic potential of erythropoietin (EPO), Salmonella typhimurium reversion assay, chromosomal aberration test on chinese hamster lung cells and in vivo micronucleus assay using mouse bone marrow cells were performed. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA102 did not increase the number of revertant at any of the concentration tested in this study. EPO did not increase the number of cells having structural or numerical chromosome aberration in cytogenetic test. In mouse micronucleus test, no significant increase in the occurrence of micro nucleated polychromatic erythrocytes was observed in ICR male mice intraperitoneally administered with EPO. These results indicate that EPO has no mutagenic effects under these experimental conditions.