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악골 결손부의 Hydroxylapatite 및 PCBM ( Particulated Cancellous bone and marrow ) 의 혼합사용시 치유과정에 관한 실험적 연구
신효근(Hyo Keun Shin),윤철희(Cheul Hee Yun) 대한악안면성형재건외과학회 1987 Maxillofacial Plastic Reconstructive Surgery Vol.9 No.1
N/A By recent studies, HAP implant showed biocompatibility with host tissue, in that no toxic or foreign body reaction was found. HAP was known to have osteophilic property but not osteogenetic ability. This study examined the healing process on histologic basis following implantation with HAP-PCBM mixture on the inferior border of rabbit mandible. The results were as follows: 1. Mild inflammatory response was observed at 1st week, but foreign body reaction and inflammatory response were not observed after 2nd week. 2. Osteoclastic, phagocytic activity was observed prominently on the grafted bone at 1st, 2nd week. Immature bone appeared at adjacent to the resorbing grafted bone. 3. New bone was boned with HAP particles directly without intervening tissue after 4th week. 4. At 8th, 12th week, mature bone was observed to have infiltrated between the HAF particles and osteoclastic activities were not noted. 5. Bony bridge between underlying cortical bone and HAP particles was observed after 4th week.