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임주영 ( Im Ju Yeong ),윤숙정 ( Yun Sug Jeong ),이지범 ( Lee Ji Beom ),김성진 ( Kim Seong Jin ),원영호 ( Won Yeong Ho ),이승철 ( Lee Seung Cheol ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.3
The common causes of eczema are known as contactant, drug, infection, atopy, and so on. Although various clinical manifestations of paraneoplastic syndrome have been described, especially in leukemia or lymphoma, intractable eczema is rarely reported to be associated with malignancy. A 55-year-old female presented with a 3-month history of pruritic erythematous papules and plaques. Oozing on the scalp, face, neck, both inguinal and inframammary areas were seen. Histopathological studies revealed a nonspecific subacute spongiotic dermatitis. The patient had been treated with prednisolone, antihistamines and antibiotics, but the skin lesions were aggravated. During the early course of eczema, laboratory findings were within the normal limits except for mild leukocytosis. Three months later, however, severe leukocytosis and cervical and inguinal lymphadenopathies developed abruptly. Computed tomography (CT) of the neck, chest, and abdomen revealed multiple lymphadenopathies to suggest lymphoma, which was confirmed later by lymph node and bone marrow biopsies, showing atypical lymphocytes extended to the bone marrow. This case shows that generalized eczema recalcitrant to conventional therapy may be associated with underlying lymphoma or leukemia (Korean J Dermatol 2004;42(3):313~316)
전진희 ( Jeon Jin Hui ),윤숙정 ( Yun Sug Jeong ),김성진 ( Kim Seong Jin ),이승철 ( Lee Seung Cheol ),원영호 ( Won Yeong Ho ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.1
Eruptive vellus hair cysts are characterized by asymptomatic, skin colored to bluish, of brownish, 1-4㎜ sized, follicular papules and nodules located on mainly anterior chest, axilla, groin, and thigh. Histopathologic examination reveals cysts containing multiple vellus hairs and the laminated keratinous materials at dermis. We reported 2 cases of eruptive vellus hair cysts developed on the unusual sites, forehead and buttock, respectively. (Korean J Dermatol 2004;42(1):74~76)
표피하 수포성 질환의 진단에서 표피 추출물 면역전사법과 Bullous Pemphigoid 180 NC16a 면역전사법의 유용성 비교
이지범 ( Lee Ji Beom ),이주영 ( Lee Ju Yeong ),윤숙정 ( Yun Sug Jeong ),원영호 ( Won Yeong Ho ),이승철 ( Lee Seung Cheol ) 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.1
N/A Background: The 180kD bullous pemphigoid antigen (BP180) is known to be recognized by sera from patients with bullous pemphigoid (BP), herpes gestationis (HG), and cicatricial pemphigoid (CP). A series of previous studies using BP180 recombinant proteins has shown that most sera from patients with BP and HG react with the NC16a domain of BP180. Objective: This study was performed to compare the immunoblotting results by using human epidermal extracts and by using recombinant protein of BP180 NC16a domain in the diagnosis of subepidermal bullous skin diseases. Method: We observed the reactivity with the epidermal extract of normal human foreskin and recombinant protein of BP180 NC16a domain in immunoblotting assay. Results: In immunoblotting with epidermal extract, 7(78%) and 6(67%) of the 9 BP sera reacted with BP230 and BP180, respectively. 1(50%) of the 2 HG and 2(100%) of the 2 CP sera reacted with BP180. In immunoblotting with recombinant protein of BP180 NC16a domain, 8(89%) of the 9 BP sera and 2(100%) of the 2 HG sera were immunoreactive. But, none of the CP and pemphigus sera reacted with the recombinant protein. Conclusion: The immunoblotting analysis using BP180 NC16a domain is a highly sensitive method without ambiguity in the diagnosis of subepidermal bullous skin diseases, and also is useful for the differential diagnosis of BP and HG from CP. (Korean J Dermatol 2004;42(1):23~28)