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윤병재(Byung-Jae Yoon),김광혁(Kwang-Hyuk kim) 대한의생명과학회 1997 Biomedical Science Letters Vol.3 No.2
1993년 1월 1일부터 1995년 12월 31일까지 부산시내 324개 사업장 16,453명의 근로자를 대상으로 성별, 연령별, 업종별 유병률을 조사하여 다음과 같은 결과를 얻었다. 조사대상자의 성별 비는 1.9:1.0이고 평균 연령은 남자가43±7세, 여자는 38±5세로 나타났다. 전체 대상자 16,453명 중 1,932명 (11.7%)이 질병을 앓고있는 사람이며 남자가 1,521명 (14.0%), 여자가 411명 (7.3%)으로 나타났다. 성별에 따른 유병률은 폐결핵, 간장질환, 소음성 난청은 남자가 여자보다 유의하게 높았고 빈혈증, 유기용제 중독은 여자가 남자보다 유의하게 높았다 (p<0.00l). 연령별 유병률은 29세 미만과 30-39세, 40-49세에서 간장질환이 높았고 50세 이상에서 순환계 질환이 높았다 (p<0.001). 업종별 유병률은 전기 건설업, 신발 고무제조업에서 순환계 질환이 가장 높았고 1차금속, 운수 정비업, 섬유 피혁, 화학 석유제조업, 기타 제조업에서 간장질환이 가장 높게 나타났다. 음료 빛 식료품 제조업과 기계제조업에 종사하는 사람은 소음성 난청이 가장 높았다. 근무 기간별 유병률은 연중독을 제외한 모든 질환에서 근무기간이 길수록 높았다 (p<0.001). This study was performed to investigat the prevalence rates disease in industrial workers (16,453) in Pusan city from Jan. 1, 1993 to Dec. 31, 1995. The results were as follows: The male to female ratio was 1.9: 1.0 and average age was 43 ± 17 in male, 38 ± 15 in female of subjects. The percentage value of patients was 14.0% in male, 7.4% in female of total patients 1,932 (11.0%). The prevalence rates' of pulmonary tuberculosis, hepatic disease, and occupational hearing loss were significantly increased in male than females (p<0.00l). But anaemia and organic solvent poisonings significantly increased in females than males (p<0.001). The prevalence rates of hepatic disease increased significantly in below 29, 30-39 and 40-49 age groups, that of cardiovascular disease increased significantly in the age group over 50 years (p<0.001). According to industrial types, the prevalence rate of cadiovascular disease increased in electricity and constration and shoes and rubber in disease, there of hepatic disease increased in primary metal, transportation and maintenance and other industrial, those of occupational hearing loss in drink and food and machinery. The prevalence rate of disease increased significantly long working duration in all diseases except lead poisoning.
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청미래 덩굴 뿌리 추출물 투여가 실험동물의 체내 중금속 함량에 미치는 영향
강혜숙 ( Hye Sook Kang ),유한춘 ( Han Choon You ),최유리 ( Yu Ri Choi ),김후경 ( Hoo Kyung Kim ),조선미 ( Seon Mi Jo ),윤병재 ( Byung Jae Yoon ) 한국식품영양학회 2011 韓國食品營養學會誌 Vol.24 No.2
Smilax china L. rhizome extract(SCE), called ``Tobokreung`` in Korean traditional medicine was investigated the influence on heavy metal contents(particularly Pb, Cd, As, and Hg) in Sprague-Dawley rats for 3 weeks. The test groups were divided into 4 group, normal, control, and SCE feeding groups, SC1(13 ㎎/㎏) and SC2(26 ㎎/㎏), respectively. The three group except normal group, were fed heavy metal such as Pb, Cd, As, and Hg. Body weight gain and the weight of target organs (liver and kidney) were determined and had not shown significant differences. Pb, Cd, and As contents in the kidney of SCE feeding groups were tended to decrease after 3 weeks, and SC2 group showed remarkably decrease of them. In the liver, the 3 heavy metal contents except Cd of SC2 group, were decreased rather than that of control group. Pb contents in the serum and the hair of the SC2 group showed significantly decreasing. All the taken together, we investigated the effect of SCE on the 4 heavy metal contents in rats for 3 weeks, and found out that more dosage of SCE made lower heavy metal contents in vivo, for the first time.
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김광혁,윤병재 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1997 Journal of biomedical laboratory sciences Vol.3 No.2
1993년 1월 1일부터 1995년 12월 31일까지 부산시내 324개 사업장 16,453명의 근로자를 대상으로 성별, 연령별, 업종별 유병률을 조사하여 다음과 같은 결과를 얻었다. 조사대상자의 성별 비는 1.9:1.0이고 평균 연령은 남자가 43±17세, 여자는 38±15세로 나타났다. 전체 대상자 16,453명중 1,932명 (11.7%)이 질병을 앓고있는 사람이며 남자가 1,521명 (14.0%), 여자가 411명 (7.3%)으로 나타났다. 성별에 따른 유병률은 폐결핵, 간장질환, 소음성 난청은 남자가 여자보다 유의하게 높았고 빈혈증, 유기용제 중독은 여자가 남자보다 유의하게 높았다 (p<0.001). 연령별 유병률은 29세 미만과 30∼39세, 40∼49세에서 간장질환이 높았고 50세 이상에서 순환계 질환이 높았다 (p<0.001). 업종별 유병률은 전기 건설업, 신발 고무제조업에서 순환계 질환이 가장 높았고 1차금속, 운수 정비업, 섬유 피혁, 화학 석유제조업, 기타 제조업에서 간장질환이 가장 높게 나타났다. 음료 및 식료품 제조업과 기계제조업에 종사하는 사람은 소음성 난청이 가장 높았다. 근무 기간별 유병률은 연중독을 제외한 모든 질환에서 근무기간이 길수록 높았다 (p<0.001). This study was performed to investigat the prevalence rates disease in industrial workers (16,453) in Pusan city from Jan. 1, 1993 to Dec. 31, 1995. The results were as follows: The male to female ratio was 1.9:1.0 and average age was 43±17 in male, 38±15 in female of subjects. The percentage value of patients was 14.0% in male, 7.4% in female of total patients 1,932 (11.0%). The prevalence rates of pulmonary tuberculosis, hepatic disease, and occupational hearing loss were significantly increased in male than females (p<0.001). But anaemia and organic solvent poisonings significantly increased in females than males (p<0.001). The prevalence rates of hepatic disease increased significantly in below 29, 30-39 and 40-49 age groups, that of cardiovascular disease increased significantly in the age group over 50 years (p<0.001). According to industrial types, the prevalence rate of cadiovascular disease increased in electricity and constration and shoes and rubber in disease, there of hepatic disease increased in primary metal, transportation and maintenance and other industrial, those of occupational hearing loss in drink and food and machinery. The prevalence rate of disease increased significantly long working duration in all diseases except lead poisoning.
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실험실적 당뇨성 흰쥐에서 acetaminophen의 대사에 관한 연구
임은주,윤병재,윤병재,조희숙,김대재,최종원 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1
Acetaminophen is one of the most important drugs used for the treatment of mild to moderate pain when an anti-inflammatory effect is not necessary. Phenacetin, a prodrug that is metabolized to acetaminophen, is more toxic than its active metabolite and has no rational indications. In this study, we were observed activities of free radical generating enzymes, free radical scavenging enzymes and glutathione-related enzymes as well as detoxification mechanism of against acetaminophen-induced hepatotoxicity in STZ-induced hyperglycemic rat. Activities of cytochrome p450, cytochrome b5, aminopyrine demethylase and aniline hydroxylase were changed by the treatment acetaminophen in hyperglycemic rats. It was also observed that activities of conjugating enzymes as sulfotransferase and UDP-glucuronyltransferase was slightly changes against acetaminophen-induced in hyperglycemic rats. Acetaminophen results in the significantly decrease in the level of hepatic glutathione concentration and √-glutamylcysteon, synthetase activities in hyperglycemic rats. And, glutathine S-transferase, superoxide dismutase and glutathione peroxidase activities were significantly increased against acetaminophen-inducedas in hyperglycemic rats. Glutathione reductase and catalase were not affected for experimental state. Furthemore, acetaminophen highered serum alanine, aspartate aminotransferase, sorbitol dehydrogenase, √-glutamylpeptidase, alkaline phosphatase and lactate dehydrogenase activities in hyperglycemic rats. Key Words: Hepatotoxicity, D/M, Acetaminophen, Glutathione, Glutathlone S-transferase, √-glutamylcystein synthetase
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