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C57BL6 마우스에서 복합생약제인 황금궁의 육모 효과
허진주(Jin Joo Hue),리란(Lan Li),유설혜(Sul Hye Lyu),백인정(In Jeoung Baek),연정민(Jung Min Yon),남상윤(Sang Yoon Nam),윤영원(Young Won Yun),황석연(Seock Yeon Hwang),홍진태(Jin Tae Hong),이범준(Beom Jun Lee) 대한약학회 2005 약학회지 Vol.49 No.6
Hwanggumgung (HGG) is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to investigate effect of HGG on hair regrowth in a shaving model of C57BL6 mice. Five-week-old mice were acclimated for 1 week under 23±3℃, 50±10% relative humidity, and 12h of a light/dark cycle before beginning experiment. There were four experimental groups including distilled water (D.W., control), 10% ethanol (EtOH, vehicle control), a positive control of 3% minoxidil (MXD), and HGG for female and male mice, respectively. Six-weeks old mice were trimmed by electric clippers so as not to damage the skin. The next day, mice without visible scraches were selected, randomized and separated in groups of 11 mice. The test compounds were topically treated with 0.15㎖ per mouse per day for 21 days. The hair regrowth was photographically and histologically determined during the experimental period of 21 days. Enzyme activities of γ-glutamyl transpeptidase and alkaline phosphatase were also determined using a rate assay method. There were no clinical signs in all experimental groups. The topical application of 3% MXD and HGG in female mice promoted hair regrowth earlier and faster than the control groups. In male mice, the topical application of 3% MXD and HGG also accelerated hair growth compared with the controls. Ten percent ethanol also promoted hair growth faster than D.W group. The histology of hair growth in experimental groups was strongly associated with the hair regrowth. 3% MXD and HGG promoted elongation of hair follicles compared with the controls in both female and male mice. Activities of alkaline phosphatase and γ-glutamyl transpeptidase, enzymes related to hair growth, significantly increased after treatments of 3% MXD and HGG for 2 weeks in both female and male mice (p<0.05). These results suggest that HGG has hair growth promoting activities and it can be for treatment for alopecia.
ScienceON
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