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RISS 인기검색어
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- 저자 : 유석천(Seok Cheon Yoo) (검색결과 2 건)
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유석천,金光鎭 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1
Lithium reabsorption occurred in the renal tubule and the lithium and sodium were conserved at that site by the same mechanism. This study was attempted to investigate the effect of lithium on the urinary excretion of electrolytes and water. Physiological saline was infused to hydrate the rabbit and collected the urine and plasma samples for control after reached steady state. After priming dose of LiCI(2mEq/kg) injected, during infusion of LiCI solution(0.2mEq/kg/hr) urine and plasma samples obtained for observation of Li^+ effect. And then 2% NaC1(NaCI group) or 0.3M sucrose(sucrose group) solution was infused to evaluate the effect on the renal function with the changes in plasma electrolyte concentration. The results obtained were summarized as follows: 1. Control urine flow rates in NaCL group was 2.28±0.03ml/10min. During Li^+ infusion the urine flow rate was increased significantly in both group. 2. Li^+ induced water diuresis with reduced urinary Na^+ and osmolar concentration while constant excretion of osmolar particles and Na^+. 3. Infusion of 2% NaC1 solution(with LiCI) persisted the water diuresis instead of increased plasma Na^+ and osmslar concentration. 4. Infusion of 0.3M sucrose solution also persisted the water diuresis with low plasma Na^+ and Li^+ concentration. 5. Plasma Li^+ concentration was significantly lowered during infusion of sucrose solution that of NaCl infusion. From the above resuls, it was suggested that water diuresis by the lithium was affected to ADH action and sucrose solution infusion reduced the effect of Li^+ on the kidney by the Na^+ countertransport mechanism with Li^+.
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