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RISS 인기검색어
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- 저자 : 유봉신(Bong-Shin Yu) (검색결과 3 건)
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이숙연(Sook-Yun Lee),유봉신(Bong-Shin Yu),문혜령(Hye-Ryoung Mun),김성경(Sung Kyung Kim) 한국생약학회 1982 생약학회지 Vol.13 No.3
Nine trace elements in Bear Galls(Fel Ursi) studied in this paper are Na, Mg, K, Ca, Cu, Zn, Fe, Pb and Ge. The contents of Na, Mg, K, Ca, Cu, Zn, Fe, Pb are determined by atomic absorption spectrometry and Ge is determined by graphite atomic absorption spectrometry. In both methods, the sample is digested with nitric-perchloric acid and then ashed. The results of analysis are shown in table and the result obtained from this study are as follows. a. The highest content of trace element of Bear Gall is Na and other elements are getting lower in order of K, Mg, Ca, Ge, Zn, Fe, Cu, and Pb. b. Particularly the content of Ge in Bear Gall was determined.
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유봉신 한국약제학회 1975 Journal of Pharmaceutical Investigation Vol.5 No.3
The rheological properties of seven mixed sugar solutions of glucose, fructose, maltose, sucrose, and two kinds of honey, the chestnut and the acacia, were discussed. The fluidity of the above samples were studied by using the applied pressure horizontal viscometer with which glycerine was confirmed to be a Newtonian flow at 25℃. Time required to pass the constant volume of the sample fluids through the capillary was measured at various pressure differences, △p, and the △p vs △p·t in the Poiseuille equation was plotted. Shear rate against shearing stress, on the other hand, was plotted for the sample fluids and it was found that all the sample fluids have shown a Newtonian behavior. It was interesting to note that the shear viscosity increased as the concentration of sugar solutions increased, and as the concentration of sucrose became higher than that of maltose, although the total concentration of sugar solution is constant.
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Metoclopramide - Polyvinylpyrrolidone 공침물에 관한 생물약제학적 연구
용재익,유봉신 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.3
In order to increase the solubility of metoclopramide, various ratio coprecipitates with polyvinylpyrrolidone (M.W. 40,000) were prepared. The experiments of the solubility, physicochemical characteristics were quantitatively developed. The solubility increased as the ratio of metoclopramide to polyvinylpyrrolidone in metoclopramide-polyvinylpyrrolindone coprecipitate increased. In powder state, the dissolution rate of metoclopramide-polyvinylpyrrolidone coprecipitate was greater than that of metoclopramide and metoclopramide-polyvinylpyrrolidone physical mixture. Dissolution characteristics of non-disintegrating disk with constant surfacearea was in accord with Noyes-Nernst equation. The intrinsic dissolution rate, G, at 37℃ was 3.98×10^(-7)M/㎠·min for metoclopramide, 2.26×10^(-6) M/㎠·min for 1 : 5 metoclopramide-polyyinylpyrrolidone coprecipitate, respectively. Accordingly, activation energy of metoclopramide was 15,061㎈/M, 9,178㎈/M for 1 : 5 metoclopramide-polyvinylpyrrolidone coprecipitate and the activation energy decreased as the coprecipitate was formed. X-ray diffraction study revealed the fact that metoclopramide was crystalline, in contrast, there was no crystallinity evident in the 1 : 5 metroclopramide-polyvinylpyrrolidone coprecipitate. There was no difference between physical mixture and coprecipitate in TLC, UV and NMR studies. From the comparision between physical mixture and coprecipitate in IR spectrum, the interaction such as association between metoclopramide and polyvinylpyrrolidone was considered. But the association was easily dissociated in methanol solution.
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