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Molecular Interacton between Adenine and Salicylic Acid Derivatives in Chloroform Solution
유병설,이상종,이승진,김낙두,한영희,Yu, Byung-Sul,Lee, Sang-Jong,Lee, Seung-Jin,Kim, Nak-Doo,Hahn, Young-Hee 생화학분자생물학회 1982 한국생화학회지 Vol.15 No.1
핵산염기인 adenine과 salicylic acid 유도체들간의 본자수준에서의 결합양식을 분광학 및 구조화학적 수단으로 측정하였다. IR 및 NMR spectra로부터 분자내에 존재하는 imino기와 carbonyl기가 상호수소결합하여 cyclic hydrogen bonded complex를 구성하고 있음을 밝힐 수 있었다. Aenine과 salicylie acid는 저농도에서 1:1 complex를 형성하며 고농도에 서는 1:2 complex를 형성한다. Aspirin의 경우도 salicylic acid와의 structural analogy에 의해 같은 양상임을 알았다. Salicylamide의 경우는 salicylie acid나 aspirin과 달리 그 결합이 약하며, 단지 1:1 complex만이 형성된다. 유사 화합물중 salicylic acid가 adenine과 가장 강한 complex를 형성하며 aspirin, salicylamide의 순으로 결합강도가 약화됨을 밝힐 수 있었다. Spectroscopic investigation has been carried out to know the binding mechanism of 9-ethyladenine with salicylic acid derivatives, such as salicylic acid, aspirin and salicylamide in chloroform solution by using infrared and nuclear magnetic resonance spectra. Adenine and salicylic acid form a 1:1 cyclic hydrogen bonded dimer in low concentration, but form a 2:1 (salicylic acid:adenine:salicylic acid) complex in high concentration. The high concentration of the sample demanded by NMR measurement has enabled us to observe this trimer formation, whereas the dilution necessary for IR method yields a concentration of trimer too small to be observed. In the case of aspirin, it is expected that the similar mode of the interaction with salicylic acid may occur because of its structural analogy with SA. The association between adenine and salicylamide is very weak unlike salicylic acid or aspirin. So, we cannot observe that 2-salicylamide: 1-adenine complex is present. Adenine and salicylamide form a 1:1 cyclic hydrogen bonded dimer. It appeared that salicylic acid forms the strongest complex among them, aspirin is second and then sailcylamide is third.
유병설,이상종,이승진,김낙두,한영희 ( Byung Sul Yu,Sang Jong Lee,Seung Jin Lee,Nak Doo Kim,Young Hee Hahn ) 생화학분자생물학회 1982 BMB Reports Vol.15 No.1
Spectroscopic investigation has been carried out to know the binding mechanism of 9-ethyladenine with salicylic acid derivatives, such as salicylic acid, aspirin and salicylamide in chloroform solution by using infrared and nuclear magnetic resonance spectra. Adenine and salicylic acid form a 1:1 cyclic hydrogen bonded dimer in low concentration, but form a 2:1 (salicylic acid:adenine:salicylic acid) complex in high concentration. The high concentration of the sample demanded by NMR measurement has enabled us to observe this trimer formation, whereas the dilution necessary for IR method yields a concentration of trimer too small to be observed. In the case of aspirin, it is expected that the similar mode of the interaction with salicylic acid may occur because of its structural analogy with SA. The association between adenine and salicylamide is very weak unlike salicylic acid or aspirin. So, we cannot observe that 2-salicylamide: 1-adenine complex is present. Adenine and salicylamide form a 1:1 cyclic hydrogen bonded dimer. It appeared that salicylic acid forms the strongest complex among them, aspirin is second and then sailcylamide is third.
인공모델막에 대한 polyene 계 항생물질의 영향 ( 1 )
유병설,김용희,손동환 ( Byung Sul Yu,Yong Hee Kim,Dong Hwan Sohn ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.1
The interaction of polyene antibiotics, amphotericin B and nystatin, with liposomes has been investigated. The activity of amphotericin B and nystatin as a function of cholesterol and ergosterol contents was studied. The polyene were added at approximate final molarities of 10^(-6)-10^(-4)M. The molar percentage of sterols was increased from 0 ㏖% to 50 ㏖%. At this concentration range, nystatin had very little effect and amphotericin B had a little stronger effect. At a higher concentration above 8×10^(-5)M, amphotericin B showed strong lytic activity on liposomes with or without sterols. These studies suggest that amphotericin B is more potent lytic agent than nystatin and that the affinites for sterols of two polyene antibiotics depend strongly on their concentrations and sterol contents.
Riboflavin과 Barbiturate와의 분자간 상호작용
유병설,이상득,이상종,정현호 대한약학회 1981 약학회지 Vol.25 No.4
Spectroscopic investigation has been carried out to know the binding mechanism of riboflavin with barbiturates, such as phenobarbital and amobarbital in chloroform solution by using infrared and nuclear magnetic resonance spectra. Phenobarbital and isoalloxazine form a 1:1 cyclic hydrogen bonded dimer through the 3-N imino and the 2-C carbonyl groups of the isoalloxazine ring of the latter, and the 1-N (or 3-N) imino and the 2-C carbonyl groups of the pyrimidine ring of the former. Amobarbital and riboflavin form a 1:1 cyclic hydrogen bonded dimer by the same mode of phenobarbital.
분광학적 방법에 의한 약물의 작용 기전 연구 및 신약 개발 검토
유병설,Yu, Byung-Sul 생화학분자생물학회 1973 한국생화학회지 Vol.6 No.1
Barbital계 화학물의 약물로써의 작용기전을 알아볼 목적으로 d-amino 산 산화효소를 사용하여 barbital이 저해제로써의 작용점을 분광학적 방법으로 스펙트럼상의 변화를 조사하여 barbital계 화합물이 저해작용을 함을 확인하였으며 병행하여 구조상 barbital과 유사한 화합물의 저해작용을 같은 방법으로 알아보고 동일한 반응을 보여준 1-methyl-5-bromouracil의 약리작용을 barbital과 비교실험하여 본 결과 분광학적 결과와 마찬가지로 유사하여 중추신경 억제작용이 있음을 밝혀냈다. The inhibition of d-amino acid oxidase by barbiturates and uracil derivatives has been studied by UV, CD and fluorescence spectra measurements. Phenobarbital and barbital are known to inhibit the activity of flavoenzyme d-amino acid oxidase. In the UV and CD spectra, 1-methyl-5-bromouracil also produced changes similar to those caused by barbiturates. Moreover, it also acts as a central nervous system depressant. Therefore, both uracil derivatives and barbiturates exhibit not only common physical properties, but also common effects in enzyme inhibition and drug action.
이온강도가 인공막의 삼투압적 성질에 미치는 영향에 대한 연구
유병설,한현숙 ( Byung Sul YU,Hyun Sook Han ) 생화학분자생물학회 1985 BMB Reports Vol.18 No.3
Multilamellar liposomes were formed spontaneously when isolated phospholipids were dispersed in glucose solution. And the effects of the amount of charged molecules in bilayer of the liposomes and the ionic strength of the medium on the forces between the bilayers of the liposomes were observed through the osmotic behavior of the liposomes using spectrophotometry. The greater the content of charged molecules, the more sensitive the osmotic behavior. The osmotic behavior of the liposomes was decreased according to the increase of the ionic strength of the glucose solution, and there was no volume change under more than 0.1 of ionic strength.
유병설,이봉진,손동환,박인원,정이남 ( Byung Sul Yu,Bong Jin Lee,Dong Hwan Sohn,In Won Park,Jeong E . Nam Shin ) 생화학분자생물학회 1988 BMB Reports Vol.21 No.2
The interactions of salicylic acid(SA) and salicylamide(SM) with nucleic acid base derivatives such as 9-ethyl adenine(A), 1-cyclohexl uracil(U), 2`,3`-benzylidine-5`-trityl-cytidine(C) and guanosine-2`,3`,5`-isobutyrate(G) have been spectroscopically investigated to determine the binding mechanism. NMR and IR spectra were measured in nonpolar solvents at very low concentration. The association constant K of the complex was calculated from the IR spectra. Compounds SA and A form a 1:1 cyclic hydrogen-bonded complex. Compounds SA and U form a 1:1 hydrogen-bonded complex. Compounds SA and C form hydrogen-bonded complex. Compound SA binds to compound G, but its binding does not completely break the self-association of compound G. Compound SM binds to compounds A, U, C and G very weakly.