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Non-clinical pharmacokinetic behavior of ginsenosides
원효중,김현일,박태준,김형민,조강희,전효진,하서준,현정민,정애리,김준식,박예진,어윤호,이재휘 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.3
Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax, have beenused as natural medicines in the East for a long time; in addition, their popularity in the West hasincreased owing to their various beneficial pharmacological effects. There is therefore a wealth ofliterature regarding the pharmacological effects of ginsenosides. In contrast, there are few comprehensivestudies that investigate their pharmacokinetic behaviors. This is because ginseng contains thecomplicated mixture of herbal materials as well as thousands of constituents with complex chemicalproperties, and ginsenosides undergo multiple biotransformation processes after administration. This is asignificant issue as pharmacokinetic studies provide crucial data regarding the efficacy and safety ofcompounds. Moreover, there have been many difficulties in the development of the optimal dosageregimens of ginsenosides and the evaluation of their interactions with other drugs. Therefore, this reviewdetails the pharmacokinetic properties and profiles of ginsenosides determined in various animal modelsadministered through different routes of administration. Such information is valuable for designingspecialized delivery systems and determining optimal dosing strategies for ginsenosides.
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