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- 저자 : 양재하(Chaeha Yang) (검색결과 2 건)
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양재하(Chaeha Yang),최성훈(Seonghun Choi) 한국한의학연구원 2009 한국한의학연구원논문집 Vol.15 No.3
Oxytocin(OT). classically known to stimulate labour and milk ejection, contributes to play an important role in a wide range of behavioral effects including drug addiction. An increasing body of evidence suggests that OT ameliorates acute and long-term effects of commonly used drugs by means of interacting with the mesolimbic dopamine system. Mesolimbic dopamine system is thought to play a major role in the reinforcing properties of drug abuse. Oxytocin receptors in the nucleus accumbens(NAc) and ventral tegmental area(VTA) have been implicated in the regulation of reinforcing effects in abused drugs. In the same way acupuncture may attenuate the reinforcing effects of abused drugs in the NAc and VTA. We have an interest in similar liaison between the substrates of acupuncture and drug addiction that may involve OT. Here, we described the possibility that acupuncture modulates the reinforcing and sensitizing properties of abused drugs in the dopaminergic system via the regulation of activities in the oxytocinergic system, The elements in this paper are summarized as follows: neuroanatomical studies of oxytocinergic innervation and distribution of oxytocin receptors: experiments related to the methamphetamine cocaine, morphine and ethanol; experiments related to the oxytocin and acupuncture.
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최성훈(Seonghun Choi),구세광(Saekwang Ku),한창현(Changhyun Han),양재하(Chaeha Yang) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.1
Objectives : The aim of present study is to examine the effect of methanolic extract from the root of Bupleurum falcatum L. (BF) on acute cocaine-induced c-Fos expression in the rat caudate putamen (CPu), a major dopaminergic terminal. Methods : Male Sprague-Dawley rats were subjected to an intraperitoneal injection with either cocaine hydrochloride (20 ㎎/㎏) or saline 30 min after an administration of either extract of BF (100 ㎎/㎏, i.p.) or vehicle. Animals were sacrificed 2 hr after treatment with cocaine or saline for immunohistochemistry. Quantification of brain slices was examined for c-Fos positive nuclei using light microscopy. Results : Pretreatment with BF significantly attenuated cocaine-induced c-Fos expression in the rat CPu. Conclusions : This finding suggests that BF has the inhibitory effect on cocaine-induced c-Fos expression in the rat CPu via possibly modulating the activities of central dopaminergic systems.
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