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안식일 ( Sik Il Ahn ),박상욱 ( Sang Wook Park ),박종학 ( Jong Hak Park ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이한구 ( Han Koo Lee ),신형식 ( Hyung Shik Shin ),이종문 ( John M Rhe 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
5-Fluorouracil(5-FU) has been widely used to treat cancer as types of iv and oral adminstration. However, it induces many side effects and has short half-life time of 10-20 minutes. Furthermore, it has low bioavailability of 20 % due to the hepatic first pass effect. Therefore, we developed novel TDDS using hydrogel and microneedle system. 5, 8 and 10% w/v of Carbopol 940NF was added in hydrogel containing 5-FU to improve permeability. Viscosity of hydrogel increased with increase of Carbopol contents. We applied these novel DDS to hairless mice skin treated and untreated with microneedle system and evaluated drug permeability into skin. The hydrogel containing 8% w/v Carbopol showed best permeability among three groups. We concluded viscosity of drug acts important factor in permeability into skin and bioavailability could be improved through our novel TDDS.
알긴산나트륨함량에 따른 BSA/PLGA미립구에서의 BSA방출거동
구정 ( Jung Ku ),박종학 ( Jong Hak Park ),안식일 ( Sik Il Ahn ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),신형식 ( Hyung Shik Shin ),이종문 ( John M. Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
We developed the BSA loaded PLGA microspheres using a sodium alginate and water-in-oil-water (W/ O/W) solvent evaporation method for sustaining release of BSA and recognized the release behavior according to sodium alginate concentration. We characterized the surface and the cross-section morphology of prepared PLGA microspheres by the SEM and behavior of BSA release from microspheres for 45 days by BCA assay method. After 45 days, the molecular weight change of PLGA was measured by GPC. The surface of microspheres appeared sphere shape and had may pores. According to sodium alginate concentration increasing, the size of microspheres increased and release rate of BSA from microspheres decreased. These results show that the change of sodium alginate concentration can control the release behaviors.
프란루카스트와 폴리(N-비닐피롤리돈)의 나노고체분산체에 의한 용출률 개선
박상욱 ( Sang Wook Park ),이준희 ( Jun Hee Lee ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),박종학 ( Jong Hak Park ),안식일 ( Sik Il Ahn ),김윤태 ( Yun Tae Kim ),신형식 ( Hyung Shik Shin ),이종문 ( John M. Rhee ),강길선 ( Gilson Kh 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
To overcome solubility of poorly water soluble drugs, we prepared solid dispersions containing nanoparticles of water insoluble pranlukast using spray dryer. These solid dispersions formulated to improve the dissolution of pranlukast. PVP-K30 used as a water soluble carrier for the solid dispersion and poloxamer used as a surfactant. Characterization of pranlukast solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and particle size analyzer. SEM and DSC were found that pranlukast is amorphous in solid dispersions. Particle size analyzer was used to investigate size of pranlukast in solid dispersions. The in vitro dissolution rate of pranlukast solid dispersion was significantly higher than the conventional drugs(Onon(R) and Prakanon (R)), as 11~33 folds. This studies illustrated the potential use of solid dispersion for the delivery of poorly water soluble drug, such as pranlukast by the oral route.