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Intracranial Pressure가 가토의 혈압 및 산-염기 평형에 미치는 영향
안광병,박해근 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2
Experiments were conducted in anesthesized rabbit. The both of femoral arteries were cannulated to measure the systemic arterial pressure with stetham transducer and to collect the arterial blood for measure the changes of acid-base parameters. The intracranial pressure (ICP) was increased by infusion of saline into the lateral ventricle through cannula. After measured the control data, ICP was increased to 50mmHg for 60 minute and released thereafter for recovery. The results are summerized as follows: 1. The arterial pressure was increasedtignificantly with elevated ICP. 2. The pH of arterial blood was significantly increased to 7.65±0.02 during a period of increased ICP and slowly recovered with decreased ICP. 3. The pCO_2 of arterial blood was significantly lowered with hyperventilation by the elevation of ICP. 4. Bicarbonate concentration and base excess were significantly decreased with elevated ICP. 5. Elevation of ICP induced respiratory alkalosis by hyperventilation and it was partially compensated by the kidney during a period of increased ICP. From the above results, was suggested that the Cushing reaction was important role in the higher ICP as well as act the additive role by the partially compensated respiratory alkalosis.
소음인(少陰人) 보중익기탕(補中益氣湯)과 후세방(後世方) 보중익기탕(補中益氣湯)이 양허병증(陽虛病證)에 미치는 영향(影響)
안광무,송일병,고병희,An, Kuang Mu,Song, Il Byung,Ko, Byung Hee 사상체질의학회 1995 사상체질의학회지 Vol.7 No.2
In order to investigate experimentally the effects of $So{\breve{u}}m$-In Bojungikit'ang and Dong-Won Bojungikit'ang on Yang-Insufficient syndrome(陽虛證) induced by Hydrocortisone acetate(HA) in experimental animals(Mice and Rats), the author experimented with various activities. Body temperature(BT), Body weight(BW), Exercise time, Cyclic-AMP, the Ra's Hair condition was measured. The results obtained are as follows : 1. In body temperature, the Dong-Won Bojungiki'ang treated group was increased significantly and the $So{\breve{u}}m$-In Bojungikit'ang treated group showed no significance. 2. In body weight, the $So{\breve{u}}m$-In Bojungikit'ang treated group had increased significantly and the Dong-Won Bojungikit'ang treated group showed no significance and there was a significant difference between the $So{\breve{u}}m$-In Bojungikit'ang and the Dong-Won Bojungikit'ang. 3. In exercise time. the $So{\breve{u}}m$-In Bojungikit'ang and the Dong-Won Bojungikit'ang treated groups were significantly increased. 4. In cyclic AMP, both experimental groups showed increasing tendancy, but showed no significance. 5. In the Rat' s hair condition. the $So{\breve{u}}m$-In Bojungikit'ang showed significance. 6. There was no significant difference between the $So{\breve{u}}m$-In Bojungikit'ang and the Dong-Won Bojungikitang except the body weight. from the above findings. (1) it has been demonstrated thet the $So{\breve{u}}m$-In Bojungikit'ang and Dong-Won Bojungikit'ang groups seem to produce the effecticeness on the recovery from depression of metabolism induced by Bydrocortisone acetate. (2) In body temperature response the Dong-Won Bojungikit'ang had effectiveness during recovery. (3) In body weight response the $So{\breve{u}}m$-In Bojungikit'ang had the effecticeness during recovery. (4) In exercise time. Both experimental group had the effectiveness during recovery. (5) In cyclic AMP response. both experimental group had no effectiveness during recovery. (6) In the Rat's hair condition response the $So{\breve{u}}m$-In Bojungikit'ang group had the effectiveness during recovery. Therefore in is suggested theat the $So{\breve{u}}m$-In Bojungikit'ang and Dong-Won Bojungikit'ang groups had effecticeness during recovery from Yang-Insufficient syndrome more of less.
少陰人 補中益氣湯과 後世方 補中益氣湯이 陽虛病證에 미치는 影響
宋一炳,高炳熙,安光武 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2
In order to investigate experimentally the effects of Soum-In Bojungikit'ang and Dong-Won Bojungikit'ang on Yang-Insufficient syndrome(陽虛證) induced by Hydrocortisone acetate(H.A.) in experimental animals(Mice and Rats), the author experimented with various activities. Body temperature(BT), Body weight(BW), Exercise time, Cyclic-AMP, the Rat's Hair condition was measured. The results obtained are as follows ; 1. In body temperature, the Dong-Won Bojungikit'ang treated group was increased significantly and the Soum-In Bojungikit'ang treated group showed no significance. 2. In body weight, the Soum-In Bojungikit'ang treated group had increased significantly and the Dong-Won Bojungikit'ang treated group showed no significance and there was a significant difference between the Soum-In Bojungikit'ang and the Dong-Won Bojungikit'ang. 3. In exercise time, the Soum-in Bojungikit'ang and the Dong-Won Bojungikit'ang treated groups were significantly increased. 4. In cyclic AMP, both experimental groups showed increasing tendancy, but showed no significance. 5. In the Rat's hair condition, the Soum-In Bojungikit'ang showed significance. 6. There was no significant difference between the Soum-In Bojungikit'ang and the Dong-Won Bojungikit'ang except the body weight. From the above findings, ① it has been demonstrated that the Soum-In Bojungikit'ang and Dong-Won Bojungikit'ang groups seem to produce the effectiveness on the recovery from depression of metabolism induced by Hydrocortisone acetate. ② In body temperature response the Dong-Won Bojungikit'ang had effectiveness during recovery. ③ In body weight response the Soum-In Bojungikit'ang had the effectiveness during recovery. ④ In exercise time, Both experimental group had the effectiveness during recovery. ⑤ In cyclic AMP response, Both experimental group had no effectiveness during recovery. ⑥ In the Rat's hair condition response the Soum-In Bojungikit'ang group had the effectiveness during recovery. Therefore it is suggested that the Soum-In Bojungikit'ang and Dong-Won Bojungikit'ang groups had effectiveness during recovery from Yang-Insufficient syndrome more or less.