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        창상 치유를 위한 생체고분자 기반 광가교형 조직접착제 개발

        이혜선,성금용,김소담,아지시 찬드라세카란,황대연,한영기,백문창,이준,양승윤 한국고분자학회 2022 폴리머 Vol.46 No.2

        Tissue adhesives are widely used in various medical fields for tissue bonding and wound closure. Existing glue-type tissue adhesives have disadvantages such as low biocompatibility or a long reaction time to achieve firm tissue adhesion. Herein we developed photocurable tissue adhesives by introducing photocrosslinkable methacrylate (MA) groups into biodegradable hyaluronic acid (HA) that enables strong tissue adhesion and wound sealing. The photocurable tissue adhesive formed a stable hydrogel layer with good tissue adhesion following short UV exposure (<5 s). By controlling the substitution rate of MA and polymer concentration, the mechanical properties and adhesion strength of the tissue adhesive could be easily manipulated. From the incisional wound animal model, the HA-based tissue adhesive used in this study showed better tissue adhesion and faster wound healing efficacy compared to commercial glues. Considering the high biocompatibility and biodegradability of HA, this photocurable adhesive would be useful in wound healing of various soft tissues.

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