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RISS 인기검색어
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- 저자 : 신형직(Hyong-Jik Shin) (검색결과 2 건)
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알코올 의존 환자에서 혈청 아질산염 농도와 일부 생물학적 지표와의 관련성
최인근(Ihn-Geun Choi),신형직(Hyong-Jik Shin),송동근(Dong-Keun Song),고재광(Jae-Kwang Koh),김상국(Sang-Kook Kim),손현균Hyun-Gyun Son),서국희(Guk-Hee Suh) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.2
Objective:Nitric oxide (NO) has been known to be associated with tolerance and preference to alcohol. It has also been known to affect various alcohol drinking behavior, alcohol withdrawal symptoms, and the alcohol-induced brain damage. The purpose of this study was to determine the difference between alcohol dependence group and healthy control group in concentration of the nitrite, a stable metabolite of NO, and it’s relationship to clinical and biochemical markers of alcohol dependence. Methods:Thirty-four subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated for the clinical characteristics and biochemical markers of alcohol dependence when their CIWA-Ar scores had reached zero after the alcohol withdrawal treatment with benzodiazepine. Thirtyfour healthy controls were also evaluated. Clinical characteristics were evaluated by CAGE and AUDIT questionnaire. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT) and mean corpuscular volume (MCV) were used as the biochemical markers of alcohol dependence. Serum nitrite concentrations were measured by Griess reaction. Results:1) The concentrations of nitrite in alcoholics were not different from those in the controls. 2) There were no significant associations between the nitrite concentration and the clinical and biological markers of alcohol dependence. 3) There was a negative correlation between the nitrite concentration and the days after last drink. Conclusion:These findings suggest that NO may be neither a causative agent nor trait marker of alcohol dependence. Rather, NO may be a state marker of recent alcohol drinking and alcohol withdrawal.
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서국희(Guk-Hee Suh),신형직(Hyong Jik Shin),함봉진(Bong Jin Hahm),조성진(Seong-Jin Cho),이동우(Dong-Woo Lee),최인근(Ihn-Geun Choi),손현균(Hyeon Gyun Son),연병길(Byeong Kil Yeon) 대한노인정신의학회 1999 노인정신의학 Vol.3 No.2
Objective : This study was to estimate the prevalence of and identify the predisposing risk factors of delirium and to determine the effect of delirium on the prognosis, especially death in burn patients. Method : The study was completed by thorough examination of medical records, with additional confirmation, of the 245 patients who were admitted to the Burn ICU in Burn treatment center of Hangang Sacred Heart Hospital during last one year (Jan. 1. 1998-Dec. 31. 1998). Delirium was retrospectively diagnosed according to DSM-IV. Only when disturbance of consciousness and attention, cognitive dysfunction –especially disorientation–, or perceptual disturbance were observed, diagnosis of delirium were given. Final outcome such as death was discriminated through examination of medical records or question to those who knew the patient. Result : One year prevalence of delirium in burn patients is 34.4%. Statistically significant predisposing risk factors of delirium were five;Age 65 and over (OR=45.51, 95% CI : 6.07-341.11), burn size over 60% of total body surface (OR=6.48, 95% CI : 3.16-13.28), current psychiatric disorder (OR=6.81, 95% CI : 1.42-32.57), current medical disease (OR=3.00, 95% CI : 1.40-6.45), alcohol abuse (OR=3.17, 95% CI : 1.07-9.43) Statistically significant deathrelated risk factors were three;burn size over 60% of total body surface (OR=4.58, 95% CI : 2.00-10.46), delirium (OR=2.94, 95% CI : 1.25-6.94), current psychiatric disorder (OR=4.09,95% CI : 1.05-15.87). Aging is not the death-related factor in this study. Conclusion : Three factors, such as delirium, organic brain damage, and burn size over 60% of total body surface may predict higher risk of death in burn patients.
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