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박정일(Jeong Hill Park),신영근(Young Geun Shin),신언경(Un Kyung Shin),백선경(Sun Kyung Baek),이승기(Seung Ki Lee),정명희(Myung Hee Chung),박영인(Young In Park) 대한약학회 1997 약학회지 Vol.41 No.4
To isolate biologically active compounds which exhibit tyrosinase inhibition activity and ultimately express skin whitening effect, 14 oriental herbal drugs were screened in terms of tyrosinase inhibition. For this purpose, in vitro enzyme assay system for tyrosinase, so called Pomerantz method with some modifications has been established. Crude methanolic extracts from 14 herbal drugs were made and examined for their inhibitory activity against tyrosinase. Those extracts fromCnidii Rhizoma, Arecae Semen, Caryophylli Flos, and Ephedrae Herba showed strong inhibitory activities on mushroom tyrosinase. Therefore, crude methanolic extracts from those 4 herbal drugs were further fractionated using ether, butanol and water. respectively. The ether and n-butanol extracts from Arecae Semen and the n-butanol and water extracts from Caryophylli Flos, respectively, showed relatively strong tyrosinase inhibitory activity compared to arbutin.
박만기(Man Ki Park),박정일(Jeong Hill Park),신영근(Young Geun Shin),신언경(Un Kyung Shin),김경호(Kyeong Ho Kim) 대한약학회 1997 약학회지 Vol.41 No.2
Three compounds were isolated from the n-BuOH fraction of buds of Eugenia caryophyllata and their structures were identified as 3,3'',4-tri-O-methylellagic acid, 3-O-beta-D-glucopyranosyl-3,5,4''-trihydroxy-7,3''-dimethoxyflavone and gallic acid by chemical and spectral evidence.