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Type IV phosphodiesterase inhibitor ( CJ-10882 ) 의 개에 대한 2 주간 경구반복투여 독성시험
차신우(Shin Woo Cha),배주현(Ju Hyun Bae),김종춘(Jong Choon Kim),김달현(Dal Hyun Kim),이근호(Koun Ho Lee),한정희(Jung Hee Han),송석범(Seog Beom Song) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.2
N/A CJ-10882, (E)-[(3-Cyclopentyloxy-4methoxyphenyl)methylene]hydrazine-carboxamide, is a newly developed type IV phosphodiesterase isozyme (PDE IV) inhibitor. To investigate the subacute toxic effects of CJ-10882, it was administered to both male and female dogs at 0, 25, 50, 100 or 200 ㎎/㎏/day orally for up to 2 weeks. During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross finding, organ weight, and histopathology were evaluated. Several clinical signs were observed in treated dogs at above 25 ㎎/㎏, including salivation and vomiting. A reduction in the body weight was observed in both sexes at above 50 ㎎/㎏. There were no treatment-related effects on mortality, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings, and histopathology in any treatment group. The results of this study demonstrate that CJ-10882, a selective inhibitor of the type IV class of PDE, may cause effects on gastrointestinal tract and salivary glands. Therefore, these organs should be closely examined in studies with other PDE IV inhibitors.