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하지 정맥류 혈관벽의 구조 및 구성 성분 변화에 대한 전자현미경학적 연구
손효성 ( Hyo Sung Son ),오창근 ( Chang Keun Oh ),이재봉 ( Jae Bong Lee ),김문범 ( Moon Bum Kim ),장호선 ( Ho Sun Jang ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.7
N/A Background : Over the years many possible explanations for the development of varicose vein have been suggested. The main possible mechanisms are a valvular failure theory and a weak wall theory. However, the definite cause of varicose has not been determined yet. Objective : The aims of this study are to observe the pathologic changes in the smooth muscle cells and extracellular matrix of the primary varicose vein. An understanding of the pathology may possibly help to understand the pathogenesis of varicose veins. Methods : A total of 20 vein specimens of primary varicose vein were collected from 13 patients who underwent ambulatory phlebectomy. Among them, 16 specimens were thick segments and 4 specimens were thin segments of varicose veins. Control samples were collected from two patients with no history and clinical evidence of varicose vein. Each specimen was examined with a JEM 1200EX-Ⅱ electron microscopy. Ultrastructural findings between thick and thin segments of varicose veins and normal veins were also compared semiquantitatively. Results : The smooth muscle cells of varicose veins were abnormal in shape and lost their fusiform appearance with many vacuoles. Increased extracellular matrix shows the increase of degenerated collagen fibers and decrease of elastic fibers. Thick segments showed increased collagen fiber. Conclusion : These ultrastructural changes may be not the primary cause of varicose veins but the secondary remodeling processes of vein walls by hemodynamic stress. (Korean J Dermatol 2003;41(7) : 899~907)
손효성,오창근,김문범,이재봉,장호선,권경술 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6
Trichorhinophalangeal syndrome(TRPS) typeⅠis characterized by sparse and slow-growing hairs, pear-shaped nose, elongated philtrum, thin upper lip, and bone deformities, especially, cone-shaped epiphyses of the phalanges. The syndrome is inherited in an autosomal dominant manner. We report a case of TRPS typeⅠ with alopecia like male pattern baldness and Perthes-like changes on the right hip joint. (Korean J Dermatol 2003;41(6) : 801~804)