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지방유래 중간엽줄기세포의 신경세포로의 전이분화 능력과 신경계 질환 치료에서 적용 가능성
이희우 ( Hee-woo Lee ),김준순 ( Jun-soon Kim ),임우석 ( Woo Seok Im ),성정순 ( Jung-joon Sung ) 서울대학교 인구의학연구소 2015 人口醫學硏究論集 Vol.28 No.-
The nervous system is essential for normal physiological function of all systems within the human body, and a complex collection of nerves and specialized cells known as neurons that transmit signals between different parts of the body. However, the nervous system has a limited capacity for self-repair. Recently, stem cell therapy using easily accessible mesenchymal stem cells, has come to as a potential therapeutic regime. Adipose tissue-derived mesenchymal stem cells (ADSCs) have the capacity to differentiate into endodermal and ectodermal cell lineage in vitro. Thus, it is important that not only is it a prerequisite to understand the functional properties of the differentiated cells, but also deciphering the regulatory pathways and mechanisms of the ADSCs themselves, suggesting that it will expedite the development and usage of ADSCs for autologous stem cell therapy in treating neurological diseases. We discuss the neural differentiation potential of human ADSCs and potential implication of these cells in treating neurodegenerative diseases.