http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
성기영,전경화,송교영,김진조,진형민,김욱,박조현,박승만,임근우,박우배,김승남,전해명,Sung, Gi-Young,Chun, Kyung-Hwa,Song, Gyo-Yeong,Kim, Jin-Jo,Chin, Hyung-Min,Kim, Wook,Park, Cho-Hyun,Park, Seung-Man,Lim, Keun-Woo,Park, Woo-Bae,Kim, Seun 대한위암학회 2005 대한위암학회지 Vol.5 No.4
목적: 위암조직에서 P16과 hMLH1 유전자의 메틸화상태를 검사하여 위암의 발생과정에서의 작용과 유전자의 발현에 미치는 영향과 Helicobacter paylori균 감염여부 및 임상병리학적인자와의 연관성을 알아보고자 하였다. 대상 및 방법: 위암 신선 동결 절편조직 100예를 대상으로 유전자의 단백질 발현상태는 면역조직화학 염색을 시행하여 확인하였고. 메틸화 상태는 methylation-specific PCR(MSP)과 염기서열분석을 시행하였다. 결과: P16유전자의 메틸화는 19예(19%)에서 관찰되었고 이 중 18예(94.7%)에서 P16유전자의 단백질 발현 소실이 있어, P16 유전자의 단백질 발현 소실이 P16유전자의 메틸화와 연관이 있음을 알 수 있었다(kappa 계수=0.317, P=.0011). hMLH1 유전자의 메틸화는 27예(27%)에서 관찰되었고, 이 중 24예(8.8%)에서 hMLH1 단백의 소실이 hMLH1유전자의 메틸화와 연관이 있음을 보여주었다(kappa계수=0.675, p<0.0001). hMLH1 유전자의 메틸화는 나이, 암종의 크기, Lauren 분류와 연관성이 있었다. P16 유전자와 hMLH1 유전자 메틸화 모두 Helicobacter paylori균 감염여부와는 연관성이 없었다. 결론: 위암에서 P16 및 hMLH1 유전자의 불활성화에는 DNA 메틸화가 작용을 함을 알 수 있었고, hMLH1유전자의 메틸화는 나이, 암종의 크기, Lauren 분류와 연관이 있음을 알 수 있었다. Purpose: We investigated the impacts of the methylation states of the P16 and the hMLH1 genes on pathogenesis and genetic expression of stomach cancer and their relationships with Helicobater pylori infection, and with other clinico-pathologic factors. Material and Methods: In our study, to detect protein expression and methylation status of the P16 and the hMLH1 genes in 100 advanced gastric adenocarcinomas, used immunohistochemical staining and methylation-specific PCR (MSP) and direct automatic genetic sequencing analysis. Results: Methylation of the P16 gene was observed in 19 out of 100 cases (19%) and in the 18 of those cases (94.7%) loss of protein expression was seen. We were sble to show that loss of P16 gene expression was related to methylation of the P16 gene (kappa coefficient=0.317, p=0.0011). Methylation of the hMLH1 gene was observed in 27 cases (27%), and in 24 cases of those 27 cases (88.8%), loss of protein expression was seen, which suggested that loss of protein expression in the hMLH1 gene is related to methylation of hMLH1 gene (kappa coefficient=0.675, P<0.0001). Also methylation of the hMLH1 gene was related to age, size of the mass, and lauren's classification. Conclusion: We found that methylation of DNA plays an important role in inactivation of the P16 and the hMLH1 genes. The methylation of the hMLH1 genes is significantly related to age, size of the mass, and lauren's classification.
성기영,박일영,이도상,김욱,백종민,신동준,원종만,이재학,Sung Gi Young,Park Il Young,Lee Do Sang,Kim Wook,Baek Jong Min,Shin Dong Jun,Won Jong Man,Lee Jai Hak 대한위암학회 2002 대한위암학회지 Vol.2 No.4
Purpose: Angiogenesis is essential for tumor growth and metastasis and depends on the production of angiogenic factors that are secreted by tumor cells. Vascular endothelial growth factor (VEGF) is the most significant angiogenic factor and a selective mitogen for endothelial cells. VEGF, also known as the vascular permeability factor, acts on endothelial cells to increase microvascular permeability and directly stimulate the growth of new blood vessels. Several studies have reported that the expression of VEGF is correlated with hematogenous recurrence via angiogenesis in gastric carcinomas. This research evaluated the relationship between the expression of VEGF and hepatic and peritoneal recurrence in gastric carcinomas. Materials and Methods: Thirty specimens resected from patients with primary gastric carcinomas who had undergone curative resections were divided into three group: Group I, early gastric carcinomas without recurrence; Group II, advanced gastric carcinomas with hepatic recurrence; and Group III, advanced gastric carcinomas with peritoneal recurrence. The expression of VEGF and the density of the microvessel count were examined using immunohistochemistry. Results: 1) The expression of VEGF in Group II and Group III ($63.2\pm\24.3\%$) was stronger than that in Group I ($7\pm\4.2\%$). The expression of VEGF in Group II ($76.5\pm\13.2\%$) was stronger than that of the Group III ($50\pm\14.2\%$) (P<0.05). 2) The microvessel count in Group II ($49.9\pm14.5$) was more than that in Group I ($8.6\pm2.6$) and Group III ($29.1\pm18.1$) (P<0.05). 3) The microvessel count was increased significantly with increasing the expression of VEGF. Conclusions: The expression of VEGF is associated with advanced stomach cancer and hepatic recurrence has a higher expression of VEGF than peritoneal recurrence with neovascularization. Thus the expression of VEGF can be considered to be a useful indicator of recurrence in gastric carcinoma and especially in hepatic recurrence.
액와접근법과 흉부접근법을 통한 내시경 갑상선 절제술의 임상적 고찰
성기영,오세정,백종민,이도상,김욱,박일영,원종만,Gi Young Sung,M,D,Se Jeong Oh,M,D,Jong Min Baek,M,D,Do Sang Lee,M,D,Wook Kim,M,D,Il Young Park,M,D,and Jong Man Won,M,D 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.1
Purpose: The thyroid suregry has recently become one of the newest fields for the application of endoscopic surgery. We have performed endoscopic thyroidectomy by an anterior chest approach and an axillary approach. In this study, we evaluated these two types of endoscopic procedures with regard to efficacy and patients' complaints after surgery.Methods: Between December 2000 and March 2002, 41 patients were treated by endoscopic thyroidectomy via axillary or anterior chest approach. Each procedure was performed by one surgeon under a general anesthesia. We analysed the operating time, postoperative complications, postoperative scar, the degree of pain to assess the surgical invasiveness of each procedure.Results: Three cases treated using anterior chest approach, and 2 cases treated using axillary approach were converted to conventional thyroidectomy. The mean age of patients was 36 years in anterior chest approach group and 30 years in axillary approach group. The operation time was 238⁑60 (160∼370) minutes in anterior chest approach and 178⁑71 (100∼295) minutes in axillary approach. Postoperative complications are; 1 case of a minimal hematoma, 3 cases of minor wound infection, 3 cases of chest pain in anterior chest approach group, and 1 case of a minimal hematoma, 1 case of transient recurrent laryngeal nerve injury, 1 cases of transient swallowing difficulties in axillary approach group.Conclusion: Endoscopic (gasless and axillary approach) thyroidectomy is a safe and effective procedure. Gasless endoscopic thyroidectomy is a useful procedure for unexperienced surgeon due to safety. Endoscopic thyroidectomy by the axillary approach is a better effective procedure with good cosmetic result for a unilateral tumor especially in young women. (Korean J Endocrine Surg 2003;4:26-30)
김영두(Young Doo Kim),성기영(Gi Young Sung),김도원(Do Won Kim),전재복(Jae Bok Jun) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.4
We report herein a case of desmoplastic trichoepithelioma in a 73-year-old female, who is the oldest among the patients of the disease reported in Korea. She had an asymptomatic, hard, annular lesion, measuring 0.6 x 0.7 cm with an elevated border and a depressed center on the left nasolsbial fold. Histopathological findings showed narrow strands of basaloid tumor cells, horn cysts and a desmoplastic stroma.
윌슨병 환자에서 다발성 섬유선종을 동반한 거대유방증 1예
김훈혁,성기영,백종민,이도상,김욱,박일영,원종만,Hoon Hyuk Kim,M.D.,Gi Young Sung,M.D.,Jong Min Baek,M.D.,Do Sang Lee,M.D.,Wook Kim,M.D.,Il Young Park,M.D. and Jong Man Won,M.D. 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.2
Wilson's disease is an autosomal recessive disorder of copper metabolism in individuals with mutant ATP7B genes. Impairment of normal excretion of hepatic copper results in toxic accumulation of the metal in liver, brain and other organs. Clinical manifestations include hepatic, neurologic or psychiatric disturbances. Penicillamine, as a chelator of copper, is the drug of choice in the treatment of Wilson's disease but after treatment of penicillamine, granulocytopenia, thrombocytopenia, the nephrotic syndrome, Goodpasture's syndrome, pemphigus vulgaris or pleural effusion may supervene. We report a case of macromastia with multiple fibroadenomas in a patient who was treated with penicillamine for Wilson's disease. (Korean J Endocrine Surg 2004;4:115-118)
최성관(Sung Koan Choi),성기영(Gi Young Seong),김도원(Do Won Kim),정상립(Sang Lip Chung) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.6
We report a case of embryonal rhabdomyosarcoma with palpable right inguinal lymph node in a 6-year-old girl which developed rapidly on the right labia minora over a period of 2 montha. Histopathological study showed characteristic findings of spindle shaped rhabdomyoblast with hyperchromatic nuclei and cytoplasmicprocesses. After a preoperative chemotherapy with vincristine, actinomycin D, and cytoxan, the size of the mass was reduced, and lymph nodes were not palpable. And then, simple vulvectomy. postoperhtive cheirnatherapy and radiotherapy were done,