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당뇨유도 백서 경골에 티타늄 임플란트 매식 시 저출력 초음파 적용이 골치유에 미치는 영향
서영교,김욱규,박상준,이수운,김용덕,황대석,Seo, Young-Kyo,Kim, Uk-Kyu,Park, Sang-Jun,Lee, Soo-Woon,Kim, Yong-Deok,Hwang, Dae-Seok 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.3
Purpose: Diabetes mellitus (DM) has been shown to alter the properties of the bone and impair bone healing around a titanium implant. The aim of this study is to investigate whether the low-intensity pulsed ultrasound (LIPUS), which has been known to stimulate the bone healing, improve the osseointegration of the titanium implant in tibia of DM-induced rats. Methods: 16 rats were received streptozotocin (60 mg/kg) for inducing diabetes. A total number of 32 titanium implants were placed bilaterally into both tibiae of these rats. The right tibia of each rat received LIPUS application (10 min/day) during 7 days post-operation, while the left side received no treatment. The study was carried on for six weeks and the rats were sacrificed at 1, 2, 4, and 6 weaks postoperatively (4 rats for each week) for histomorphometric and histologic analysis. Bone-implant contact and bone area were measured. Comparisons between the groups were made using statistical analysis on histomorphometric analysis. Results: The histomorphometry parameters showed that the bone-implant contact and the bone area values have decreased in the late osseointegration periods (4, 6 weeks) compared to the early osseointegration periods (1, 2 weeks) in both two groups. The bone-implant contact values of the LIPUS group were somewhat higher than those of controls at 1, 2 weeks, but the difference was not statistically significant. The bone area values of the LIPUS group were also higher than those of controls at 1, 2 weeks, but the difference was not statistically significant as well. Conclusion: Results of this study indicate that LIPUS may have positive effects on early osseointegration but could not improve the long term stability of dental implants.
백서 도상 피부피판에서 허혈-재관류 손상의 예방: Histamine 수용체 봉쇄약물과 L-arginine의 효과 비교
서영교,김욱규,Seo, Young-Kyo,Kim, Uk-Kyu 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.4
Vascular thrombosis and ischemic necrosis still remain the most significant threats to the survival of free flaps. To date, neutrophils have been implicated in the pathogenesis of postischemic injury. Several studies have demonstrated that modulating the neutrophil response to ischemia-reperfusion injury can decrease the extent of the injury. In addition, some authors noticed that mast cell counts were also increased in flaps exposed to state of ischemia/reperfusion. So, we designed to evaluate the role of mast cells in ischemia/reperfusion by blocking histamine and to compare the effect of L-arginine, a nitric oxide precursor which is known to prevent neutrophil-mediated tissue injury. Epigastric island skin flaps were elevated in 30 rats and rendered ischemic. Thirty minutes prior to reperfusion, the rats were treated with intraperitoneal saline, diphenhydramine, cimetidine, and L-arginine. The necrosis rate of flap at 7 days, the number of neutrophils and mast cells at 20 hours were evaluated. In conclusion, histamine receptor blockers as well as L-arginine significantly decreased flap necrosis in a rat skin island ischemia-reperfusion flap model, but the protective effect was not significantly different in both agent groups.
송현석(Hyun-Seok Song),서영교(Young-Kyu Seo),정도현(Do-Hyun Jung),장중순(Joong-Soon Jang),김은규(Eunkyu Kim),박부희(Boo-Hee Park) 한국신뢰성학회 2017 신뢰성응용연구 Vol.17 No.3
Purpose: The purpose of this study is to estimate the lifetime of commercial passenger vehicles shock absorber using degradation test and data. Method: The degradation factor of shock absorber was determined to be a damping force using FMEA. Degradation test was performed on damping force under real world usage condition and analysed the degradation data. Results: To estimate the lifetime of shock absorber, a degradation model was developed and a numerical example was provided. Conclusion: Evaluation of the lifetime of commercial and military vehicles shock absorber will be possible by using the proposed degradation analysis method.