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Macrophage Inflammatory Protein-1α의 浩血幹細胞 억제 작용에 관한 실험적 연구
고승오,서기향,신효근,김오한 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.2
The proliferation of bone marrow stem cell compartment is thought to be under both positive and negative controls by cytokines and colony stimulation factors. Macrophage inflammatory protein-1α(MIP-1α) has been assessed for its potential to protect hematopoietic stem cells from cytotoxic effects of a cycle-specific antineoplastic agents. We have tested the ability of MIP-1α to suppress the proliferation of stem cell line Du.528.101 in variety of active status by using [³H]-thymidine incorporation test. The results were as follows. 1. The effect of MIP-1α on steady-state Du.528.101 cell represented the cell growth suppression at the concentration of 10, 50, 100nM of MIP-1α(P<0.001). 2. MIP-α stimulated the proliferation of Du.528.101 cells previously treated with IL-1 at the concentration of 5, 50nM of MIP-1α(P<0.01) 3. The suppression effect of MIP-1 on Du.528.101 cells at the concentration of 5, 50nM was shown when cells were treated with MIP-1α before activation with IL-1β(P<0.01). 4. The growth rate of synchronized cells were slower than that of non-synchronized ones, and MIP-1α represented the similar suppression effect on both synchronized and non-synchronized cells.