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임상연구 : Schnider 약동학모델을 이용한 Propofol의 목표효과처농도조절주입: 성별 및 연령별 비교
태자윤 ( Ja Yoon Tae ),백희정 ( Hee Jung Biak ),김윤진 ( Youn Jin Kim ),김종학 ( Jong Hak Kim ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.1
Background: We investigated effect-site median effective concentration (EC50) of propofol for loss of consciousness and effect-site concentration at each anesthetic stage and awakening time to compare the differences by gender or age of patients using Schnider model. Methods: Total 91 patients were allocated into 4 groups: male patients aged 18-34 year (Group 1), male patients aged 35-55 years (Group 2), female patients aged 18-34 years (Group 3) and female patients aged 35-55 years (Group 4). The effect-site EC50 for loss of consciousness was calculated and the effect-site concentration of propofol at each anesthetic stage and the awakening time of each group were recorded. Results: The effect-site EC50 of propofol for loss of consciousness was 4.53 ± 0.30μg/ml, 4.60 ± 0.25μg/ml, 4.13 ± 0.39μg/ ml and 4.47 ± 0.65μg/ml in group 1, 2, 3, and 4, respectively. The effect-site concentrations in male patients aged 18-34 years were significantly higher than those in female patients. The awakening time of female patients aged 35-55 years was shorter than that of male patients. Conclusions: There were no significant differences of effect-site EC50 for the loss of consciousness of propofol with target effect-site controlled infusion by Schnider model among the groups. However the effect-site concentrations and the awakening time of propofol by Schnider model showed differences in patients` gender and age. (Korean J Anesthesiol 2007; 53: 27~34)
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