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인간 전분화능줄기세포의 대량 배양을 위한 마이크로캐리어(microcarrier) 배양 시스템
배진아 ( Jin Ah Baek ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2014 人口醫學硏究論集 Vol.27 No.-
Human pluripotent stem cells (hPSCs) have been a prime candidare cell source for the development of cell replacement therapies and regenerative medicine because they can self-renew and maintain the pluripotency. The use of hPSCs for clinical applications requires a scalable, continuous propagation and controlled process for clinically relevant quantities. However, the conventional culture techniques of hPSCs are two-dimensional(2D) systems, which are associared with low production yields. In order to overcome these issues, several groups have developed to culture hPSCs on microcrriers and they demonstrated that is more robust and feasible for scale-up than traditional 2D cultures. The cultivation of hPSCs on microcarrier culture system is relatively novel in the field of stem cells, so more researches are needed in several critical issus: coatings, medium development and improved bioprocess parametecrs for opcimal hPSCs systems.