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RISS 인기검색어
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- 저자 : 박명환(Myung Hwon Park) (검색결과 2 건)
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간장질환 치료용 의약조성물 ( DWP 305 ) 의 이반약리작용
심점순(Jeom Soon Shim),박남준(Nam Jun Park),유영효(Young Hyo Yu),임승욱(Seung Wook Lim),염제호(Je Ho Yeom),김영만(Young Man Kim),장병수(Byeong Su Jang),박명환(Myung Hwon Park),연제덕(Je Duk Yeon),김병오(Byung O Kim),강진석(Jin Seok K 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.2
The general and some pharmacological actions of DWP 305 were investigated in animals and the following results were obtained. In central nervous system, DWP 305 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in mice and body temperature in rat. DWP 305 showed no depressive action on convulsion induced by strychnine, electronic shock and pentylenetetrazole. From these results, DWP 305 was considered to have no pharmacological effect on the central nervous system. Furthermore, DWP 305 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 305 inhibited contrastive effects against the acetylcholine (10^(-6)g/㎖), histamine (10^(-6)g/㎖), 5-hydroxytryptamine (10^(-6)g/㎖) and BaCl₂ (10^(-4)g/㎖) at a concentration of 2.15 X 10^(-4)g/㎖ in bath. In the isolated trachea and vas deference, DWP 305 showed no effect on the contractions produced by histamine and norepinephrine, respectively. DWP 305 showed inhibitory effect on the contractions produced by acetylcholine and oxytocin at a concentration of 2.15 X 10^(-4)g/㎖ on the isolated nonpregnant rat uterus. DWP 305 had no effect on the isolated right atrium of guinea pig, bile excretion urine volume, pH, gastrointestinal motility, gastric secretion and blood aggregation.
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위장질환 치료용 의약조성물 (DWP 302) 의 일반약리작용
김영만,남권호,유영효,임승욱,염제호,장병수,김동오,박명환 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
The general and some pharmacological actions of DWP 302 were investigated in animals and the following results were obtained. In central nervous system, DWP 302 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in the mice and body temperature in the rat. DWP 302 showed no depressive action on the convulsion induced by strychnine and electronic shock. From these results, DWP 302 was considered to have no or little pharmacological effect on the central nervous system. Furthermore, DWP 302 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 302 showed neither contractive nor relaxing effects against the acetylcholine (10^(-6) g/ml), histamine (10^(-6) g/ml) and BaCl₂ (10⁴g/ml) at a concentration of 1.9X 10⁴g/ml in bath. But it caused a slight increase in basal tone at a concentration of 6.3 X 10^(-4) g/ml and this effect was inhibited by atropine 10^7 g/ml. In the isolated trachea and vas deference, DWP 302 showed no effect on the contractions produced by histamine and norepinephrine, respectively. And DWP 302 showed no effect on the contractions producd by acetylcholine and oxytocin in the isolated nonpregnant rat uterus. DWP 302 had no effect on bile excretion, urine volume, pH and gastrointestinal motility. But, DWP 302 showed a significant inhibitory effect on gastric secretion in the rat.
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