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RISS 인기검색어
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- 저자 : 문홍섭(Hong Seog Moon) (검색결과 2 건)
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최준식(Jun Shik Choi),문홍섭(Hong Seog Moon),최인(In Choi),범진필(Jin Pil Burm) 대한약학회 1996 약학회지 Vol.40 No.1
The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korean normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were 0.226 +/- 0.032, 0.231 +/- 0.063L/Kg and 0.357 +/- 0.024, 0.337 +/- 0.041hr-1 for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters, KS and VS were 0.00344 +/- 0.00049(hr.ml/min/1.73m2)-1 and 0.214 +/- 0.0502L/Kg for gastrointestinal surgical patients using NPEM method. The V and K were 0.216 +/- 0.048L/Kg and 0.336 +/- 0.043hr-1 for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetics between NLSR and Bayesian analysis in gastrointestinal surgical patient.
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최준식,문홍섭,최인,범진필 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
The purpose of this investigation was to determine pharmacokinetic parameter of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korea normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were 0.226±0.032, 0.231±0.063 L/㎏ and 0.357± 0.024, 0.337±0.041 hr^-1 for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters. KS and VS were 0.00344±0.00049(hr·mL/min/1.73㎡)^-1 and 0.214±0.0502 L/㎏ for gastronintestinal surgical patients using NPEM method. The V and K were 0.216±0.048 L/㎏ and 0.336±0.043 hr^-1 for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetic between NLSR and Bayesian analysis in gastrointestinal surgical patient.
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