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- 저자 : 마진열(Jin Yeal Ma) (검색결과 1 건)
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난소적출 흰쥐를 이용한 칡 발효액이 골다공증 예방 효과에 미치는 영향 연구
마진열(Jin Yeal Ma),이정운(Jung Woon Lee),김동현(Dong Hyun Kim),이영철(Young Chul Lee),나혜숙(Hye Sook Na),지옥표(Ok Pyo Zee) 대한약학회 2005 약학회지 Vol.49 No.6
In our study, osteoporosis was induced by ovariectomized in female Sprague-Daweley rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal Type I pattern was examined by using the experimental substance soybeans and arrowroot. After ovariectomy, the amount of estrogen was found to be reduced by 21.37% and it showed the tendency to be increased by 4.49% in T1 (extraction of soybeans group) and 7.62% in T2 (extraction of ferment soybeans group). The change of bone density, 14 weeks after ovariectomy in the femur, was decreased by 9.33% in N.C. group, and 5.46% in T3 (extraction of ferment arrowroot group). As pathological findings, the trabeculae of femur were detected to be abundant as normal and the frequency of the appearance of osteoclasts was very minimal. In the T3, the frequency of the appearance of the trabeculae of femur was increased to the level that could be distinguished. In regard to the accumulation of lipid in the bone marrow, the accumulation of lipid in the bone marrow was low as normal. However, in T3, the decrease to the level that could be distinguished was detected. In addition, in regard to the pathological findings of the uterus, normal uterine tissue findings were detected. In the T3, the minimal atrophy findings were detected. In conclusion, when the T3 was orally administered continuously for 14 weeks, it was thought that a certain proportion of the hormonal balance was maintained that functioned as a substance interfering the accumulation of fat, and it was considered to be of help in the treatment of not only osteoporosis Type I, but also for the prevention and treatment of various endocrinal diseases.
ScienceON
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