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배뇨 장애를 호소하는 뇌경색 환자의 가미금궤신기환 치험 2례
노동진 ( Dong Jin No ),박장호 ( Jang Ho Park ),유윤선 ( Yun Sun Lyu ),이고은 ( Go Eun Lee ),박인숙 ( In Sook Park ),류영수 ( Yeoung Su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.2
Objectives: The purpose of this study is to examine the effect of Gamigumguesingi-hwan(Jiaweijinkuishenqi-wan) against urinary frequency. Methods: Gamigumguesingi-hwan(Jiaweijinkuishenqi-wan) is known as a useful herbal medication for urinary fequency. So we treat two patients with Gamigumguesingi-hwan( Jiaweijinkuishenqi-wan) three times a day. By investigating the frequency of urine, we can get some data. Results: One patient`s nocturia frequency was counted 10 times to 3 times and voided volume was increased. The other patient`s nocturia frequency was counted 10 times to 3~4 times. Conclusions: Gamigumguesingi-hwan( Jiaweijinkuishenqi-wan) is effective in urinary frequency and nocturia.
가미귀비탕(加味歸脾湯)이 P815 세포의 serotonin 대사 과정에 미치는 영향
노동진 ( Dong Jin No ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.1
Objectives: This study was perfomed to investigate the antioxidant activity and serotonin activity of Gami-guibi-tang on P815 Mast Cell. Methods: The effects of Gami-guibi-tang on activation of TPH-1 mRNA and AAADC mRNA in P815 mast cell were investigated. The effect of Gami-guibi-tang on content of serotonin in P815 mast cell was investigated. The effects of Gami-guibi-tang on activation of DPPH radical-scavenging and SOD in P815 mast cell were investigated. Results: 1. The Gami-guibi-tang increased SOD activity and DPPH radical-scavenging activity. 2. The Gami-guibi-tang increased the intracellular concentration of serotonin in 60 ㎍/㎖, 80 ㎍/㎖ experiment group. 3. The Gami-guibi-tang increased menaingful the manifestation TPH mRNA. 4. The manifestation of AAADC and MAO mRNA have not made menaingful changes on Gami-guibi-tang. Conclusions: This experiment shows that Gami-guibi-tang had significant anti-oxidative effect. And Gami-guibi-tang increased the intracellular concentration of serotonin. Therefore, Gami-guibi-tang can be used by the medication of major depression disorder. But Study on mechanism of increased serotonin and clinical research of Gami-guibi-tang is suggested for future research.
노동진 ( Dong Jin No ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.4
Objectives: To address suitable method for designing clinical trial intervening Traditional Korean Herbal Medicine on General anxiety disorder through the recent clinical reserch in Chinese Herbal Medicine. Methods: Randomized, controlled trials(RCTs) of treatment of general anxiety disorder intervening herbal medicine were searched through CNKI databases. We examined several item of studies and evaluated using Jadad scale. We searched articles in CNKI with the key word "General anxiety disorder or 廣範性焦慮症", among them we selected the clinical trial studies related with herbal medicine except for case reports, studies of acupuncture therapy or west medicines. Results: 11 RCT studies of herbal medicine met inclusion criteria. The Studies used CCMD-3, HAMA as inclusion tool and mainly HAMA as a evaluation tool. Studies were progressed for 2-8 weeks, mostly used various positive control. Experiment medicine were mainly 理氣劑, 安神劑. In most studies, experiment group made similar or higher efficacy in comparison with control group. Mean Jadad score of studies was 1.36±0.67, and only one study was double-blinded among 11 studies. Conclusions: RCT studies on general anxiety disorder of chinese herbal medicine tend to focus on investigating effect of herbal medicine through setting positive control group with CCMD-3 and HAMA. But, most studies had low quality of trial, for lack of pattern identification, evaluation and inclusion tool of chinese medicine. Clinical trials of general anxiety disorder should provide good quality by randomization, double-blinding, and multi-site trial.