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일차배양 간세포를 이용한 Nitric Oxide(NO)의 항산화 활성 및 약물대사 효소에 미치는 영향
남성윤,정연봉,김동석,이종철 慶星大學校 1996 論文集 Vol.17 No.2
The purpose of the present study was to determine the antioxidative activity and effects on drug metabolism of nitric oxide. In experiments, the incubation of isolated rat hepatocytes with lipopolysaccharide(LPS) resulted in the slight inhibition of lipid peroxidation but superoxide productivity not affected. Also LPS increased intracellular glutathione and glutathione S-transferase activity. In contrast, N??-monomethyl-L-Arginine (L-NMA), an inhibitor of both the constitutive and inducible nitrix oxide synthases, decreased in lactate dehydrogenase. And, LPS inhibited increasse of ethoxycoumarin O-deethylase activity by phenobarbital, but other monooxygenase activity not affect. Treatment of L-NMA to phenobarbital -pretrteated rat hepatocytes results in slight increase of cytochrome P-450 I Al specific enzyme ethoxyresorufin O-deethylase activity.
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드릅나무(Aralia elata) 부탄올 추출물의 항암 및 면역 활성에 미치는 영향
김용규,남성윤,정연봉,이종철 慶星大學校 1994 論文集 Vol.15 No.2
The butanol fraction from the bark of Aralia elata SEEM(Araliaceae) showed marked antitumor and cytotoxic activity. The solid tumor growth inhibition ratio of the BuOH fraction againse sarcoma-180 was at highest level of 74.15% while administrating in the concentration of 100mg/Kg/day and life prolongation ratio showed 52.75% in the concentration of 100mg/Kg/day. In incubation of sarcoma-180 tumor cell with BuOH fraction, viability was 15.73%, the direct cytotoxic activity of Aralia elata was remarked in vitro. But the administered group being compared with the controlled group, no significant changes revealed in the immune reaction.
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이종철,남성윤,정연봉 慶星大學校 1995 論文集 Vol.16 No.2
In this research, we examined the effect of Prunus mume and Loranthi ramulus on the active oxygen in CCI₄induced rats. In rat liver homogenate intoxicated with CCI₄(0.5ml/100g),BuOH fraction of Prunus mume and Loranthi ramulus showed a remarkable inhibition of the lipid peroxidation. And Prunus mume reduced the superoxide productivity by CCI₄about 30%, but the inhibition by Loranthi ramulus was small in contrast with Prunus mume. In the group of Prunus mume treatment, the contents of protein bound-SH, and glutathion and the activity of glutathion S-transferase was recovered to the normal level but the effect of the Loranthi ramulus was small in contrast with Prunus mume.
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열벽 증착 방법으로 성장한 ZnTeCu 박막의 전기적 특성
박성래(S.G.Park),남성윤(S.G.Nam),오병성(B.S.O),이기선(K.S.Lee) 한국태양에너지학회 1997 한국태양에너지학회 논문집 Vol.17 No.3
열벽 증착(hot-wall evaporation)방법으로 Cu를 첨가한 ZnTe박막을 성장하였다. doping을 하지 않은 ZnTe박막의 전기 전도형은 p-형으로 전기 전도도는 10^-6(Ω·cm)^-1을 정도로 매우 낮았다. 첨가한 Cu의 양에 따라 전기 전도도는 10²(Ω·cm)^-1까지 증가하였으나 이동도는 크게 변하지 않았다. Cu를 매우 많이 첨가한 경우는 금속과 같은 전기 전도도를 관찰하였다. Cu-doped ZnTe thin films have been grown by hot-wall evaporation. The electrical conductivity of the intrinsic ZnTe film was of p-type and as low as 10^-6 (Ω·cm)^-1. As the doped Cu concentration was increased, the electrical conductivity was increased up to 10²(Ω·cm)^-1, but the mobility was decreased a little. The heavily doped sample shows the metal-like electrical resistivity.
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