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교재중심 강의와 문제중심학습 방식이 기초의학에서 과학적 추론에 미치는 효과 비교
김현아,김각균,이승우,Kim, Hyeon-A,Kim, Kack-Kyun,Lee, Sung-Woo 대한안면통증구강내과학회 2005 Journal of Oral Medicine and Pain Vol.30 No.1
Purpose: The aim of this preliminary study was to evaluate the effect of Problem-Based Learning (PBL) curriculum on development of comprehension of basic medical knowledge and quality of semi-structured problem solving including scientific reasoning skill. This scientific reasoning contained five components including: size of simple, design of research cause-effect, construction of risk factor, analysis statistic of data, interpretation of result. Materials and Methods: Seoul National University Dental students (100) participated in this experience during two weeks, 2004. Forty eight multiple-choice questions (MCQ) concerned "Infection Control and Prevention" were asked before and after two sections of Lecture-Based Learning (LBL) and PBL (pretest-posttest control group design). A semi-structured problem in epidemiological research was asked to these students after two sections (posttest-only control group design). Data (mean and SD) were analysed using the t Test for two independent samples (p<.05), comparing PBL versus LBL. Results: Our analyse of scores show no difference between LBL and PBL in the development of comprehension of "Infection Control and Prevention". The quality problem solving (epidemiological research) was significantly different between the two groups (p=.029); specially, two components' scores of reflection on scientific reasoning cause-effect (p=.000) and interpretation of result (p=.001) were significantly better for PBL than for LBL. Conclusion: Theses results indicate that comparing LBL and PBL, PBL curriculum have not been disadvantaged in comprehension of basic knowledge, and have contributed to develop the scientific reasoning in problem solving.
지방산 조성과 Butylated Hydroxytoluene이 2-acetylaminofluorene을 투여한 쥐간의 지질 과산화물 방어 효소체계에 미치는 영향
김현아,김현덕,최혜미,이주희,Kim, Hyeon-A,Kim, Hyeon-Dug,Choi, Hay-Mie,Lee, Ju-Hee 생화학분자생물학회 1990 한국생화학회지 Vol.23 No.3
이유된 Sprague Dawley종 숫쥐를 8주간 0.3% butylated hydroxytoluene(BHT)을 넣거나 넣지 않는 soybean oil과 beef tallow를 15% 수준으로 먹이고 9주째 2-acetylaminofluorene(AAF)을 복강으로 주사한 뒤 간 microsome과 cytosol 분획에서 지질 과산화물 함량, superoxide dismutase(SOD), glutathione(GSH) peroxidase, glutathione(GSH) S-trasferase 활성도와 cytochrome P-450의 함량을 측정하였다. AAF가 지질 과산화물 함량과 SOD 활성도에 미치는 영향은 두 식이군에서 유의적인 차이를 보이지 않았다. GSH peroxidase 활성과 cytochrome P-450 함량은 체중 kg당 25mg의 AAF를 투여시 두 식이군에서 모두 증가하였다. 체중 kg당 100mg의 AAF를 투여시 GSH peroxidase 활성도는 soybean oil군에서는 감소하였고 beef tallow군에서는 증가하였다. GSH S-transferase의 활성도는 두 식이군에서 모두 AAF의 투여에 비례하여 증가하였고 식이지방과 BHT는 효소 활성도에 유의적인 영향을 미치지 않았다. 이상의 결과는 불포화지방 식이와 AAF의 투여가 간 microsome의 지질 과산화를 증가시킬 것이나 지질 과산화물에 의해 cytosol의 GSH peroxidase와 GSH S-transferase의 활성도가 증가하여 지질 과산화물을 효과적으로 대사 시켰음을 시사한다. This study examines the effects of AAF levels and BHT on lipid peroxide metabolizing enzymes in rats fed different dietary fats. Weanling Sprague Dawley male rats were fed beef tallow and soybean oil at 15% with or without 0.3% BHT for 8 weeks. At 9th week, AAF was injected at the level of 25 mg and 100 mg/kg body weight. The lipid peroxide values and cytochrome P-450 contents were determined in liver microsomal fraction, and SOD, GSH peroxidase, GSH S-transferase activities in cytosolic fraction. Effects of AAF on lipid peroxide values and SOD activities were not significantly different. GSH peroxidase activities and cytochrome P-450 contents were elevated at 25 mg AAF in both dietary groups. At 100 mg AAF, GSH peroxidase activities were lowered in soybean oil group, but elevated in beef tallow group. GSH S-transferase activities were elevated by AAF and correlated to the levels of AAF positively in both dietary groups. These results suggest that polyunsaturated fat diet and AAF might increase microsomal lipid peroxidation, but GSH peroxidase and GSH S-transferase activities were elevated by lipid peroxide and metabolized lipid peroxide effectively.
지방산 조성과 Butylated Hydroxytoluene 이 2 - acetylaminofluorene 을 투여한 쥐간의 지질 과산화물 방어 효소체계에 미치는 영향
김현아,김현덕,최혜미,이주희 ( Hyeon A Kim,Hyeon Dug Kim,Hay Mie Choi,Ju Hee Lee ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.3
This study examines the effects of AAF levels and BHT on lipid peroxide metabolizing enzymes in rats fed different dietary fats. Weanling Sprague Dawley male rats were fed beef tallow and soybean oil at 15% with or without 0.3% BHT for 8 weeks. At 9th week, AAF was injected at the level of 25 ㎎ and 100 ㎎/㎏ body weight. The lipid peroxide values and cytochrome P-450 contents were determined in liver microsomal fraction, and SOD, GSH peroxidase, GSH S-transferase activities in cytosolic fraction. Effects of AAF on lipid peroxide values and SOD activities were not significantly different. GSH peroxidse activities and cytochrome P-450 contents were elevated at 25 ㎎ AAF in both dietary groups. At 100 ㎎ AAF, GSH peroxidase activities were lowered in soybean oil group, but elevated in beef tallow group. GSH S-transferase activities were elevated by AAF and correlated to the levels of AAF positively in both dietary groups. These results suggest that polyunsaturated fat diet and AAF might increase microsomal lipid peroxidation, but GSH peroxidase and GSH S-transferase activities were elevated by lipid peroxide and metabolized lipid peroxide effectively.
김현아,Kim, Hyeon-A 한국주택협회 2007 주택과 사람들 Vol.202 No.-
정부가 지난 1월 31일 부동산 대책을 또 내놨다. 장기 임대 주택을 지속적으로 확대 공급하겠다는 게 골자다. 또한 새롭게 펀드형 임대주택이라는 방식까지 제안하고 있다. 임대 주택의 실효성 여부와 이것이 주택 시장 전반에 미치는 영향에 대해 알아보자.
김현아,Kim, Hyeon-A 한국주택협회 2006 주택과 사람들 Vol.196 No.-
전국이 투기지역, 투기 과열지역, 주택거래 신고지역으로 꽁꽁 묶여 있다. 너무나 많은 지역을 부동산 규제지역으로 묶어놓은 탓에 주택 거래가 더욱 힘들어지고 있다. 주택 가격이 다소 안정세를 보이는 요즘은 부동산 규제지역 정비가 필요한 시점이다. 이에 따라 부동산 규제지역 정비가 필요한 이유와 개선 방안에 대해 알아보자.
미분양으로 인한 건설사들의 경영난-빠른 대책없으면 심각한 내수 침체 가능성
김현아,Kim, Hyeon-A 한국주택협회 2008 주택과 사람들 Vol.219 No.-
건설사들이 미분양과 원자재 가격 상승이라는 '이중고'에 시달리고 있다. 지방에서 시작된 미분양이 수도권까지 확산되면서 1995년의 역대 최대 미분양 사태와 비교되며 장기화될 조짐을 보이고 있다. 대외 경제 여건 악화와 원가 상승, 금리 인상까지 겹쳐 더욱더 어려워질 것으로 보이는 건설사들의 경영난을 들여다봤다.