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Cystein-Aβ42 폴리펩티드가 β-아밀로이드의 응집력에 미치는 영향
김익균 ( Ek Yune Kim ) 대구가톨릭대학교 자연과학연구소 2013 자연과학연구논문집 Vol.11 No.1
Alzheimer``s disease (AD) is a neurodegenerative disease caused by the deposition of Ab plaque in the brain. β-secretase known as BACE-1 and g-secretase have been identified as the key proteases responsible for processing the Amyloid Precurs or Protein(APP) to the 40 or 42 residue β-amyloid peptide(Aβ). Albeit the deposition of Aβ is a crucial role in AD, but little is known about regarding of its accumulation process. In this study, we have produced recombinant cystein- A β 42 polypeptide and demonstrated its possible role in deposition of Aβ plaque in invitro level. The cystein- Aβ 42 subject showed two high molecules bands compare to control subject. These results might imply that the aggregated forms of cysteine coupled Aβ 42 may use development of amyloid β-protein yields novel therapies for Alzheimer disease.