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피부의 병리소견이 피부이완증과 유사한 고전형 Ehlers-Danlos 증후군
김의경 ( Ui Kyung Kim ),남현민 ( Hyun Min Nam ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.6
Ehlers-Danlos syndrome is a connective tissue disorder that is characterized by hyper-extensible skin, hyper-mobile joints, fragile tissues, bleeding diathesis and poor healing of wounds with cigarette paper scar formation. Cutis laxa is also a disease of the elastic fibers of the connective tissue and characterized by loose skin folds over all parts of the body, a prematurely aged appearance, a hooked nose with a short colummella and umbilical/inguinal hernias. We report here on two patients who showed the symptoms of Ehlers-Danlos syndrome with histopathologically reduced and distorted elastic fibers, which is usually seen in cutis laxa. (Korean J Dermatol 2011;49(6):524∼528)
옻에 의한 전신접촉피부염과 정상 피부에서 항원제시세포의 차이
김의경 ( Ui Kyung Kim ),최금하 ( Keum Ha Choi ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.3
Background: Urushiol is a widely known potent allergen that causes severe contact dermatitis through the epidermis or blood vessels. The role of antigen presenting cells (APC) in allergic contact dermatitis (ACD) is well known, but the role of APC in systemic contact dermatitis (SCD) is not yet fully evaluated. Objective: The aim of this study is to observe the changes of APC in thenormal and SCD skin and to discuss their possible roles in the disease process. Methods: Immunohistochemical differences of the Langerhans cells (LC) and dermal dendritic cells (DDC) were investigated in cases of the normal and SCD skin (Ed note: keep uniformity as above). Immunohistochemical staining with anti-CD1a, S-100 protein, HLA-DR, and factor XIIIa antibodies were performed. The number of CD1a, S-100 protein, and HLA-DR positive cells per mm2 of the epidermis was counted. The number of HLA-DR and Factor XIIIa-positive DDC per mm2 was also evaluated. Results: The LC positive for CD1a and S-100 in the epidermis were slightly higher in SCD, but their difference was not statistically significant. HLA-DR and Factor XIIIa-positive DDC in the dermis weresignificantly increased in the skin of SCD than normal. HLA-DR positive LC in the epidermis was also increased. Conclusion: Our results suggest that DDC plays a more important role than that of epidermal LC in urushiol-induced SCD. Increased HLA-DR-positive LC in the epidermis suggests that antigen delivery through the blood also affects the epidermal Langerhans cell beside the dermal dendritic cells. (Korean J Dermatol 2013;51(3): 179∼184)
피부에 국한하여 잦은 재발을 보인 이차성 피부 미만 B대세포 림프종
김의경 ( Ui Kyung Kim ),남현민 ( Hyun Min Nam ),박석돈 ( Seok Don Park ),박건 ( Kun Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.11
We report a case of cutaneous diffuse large B cell lymphoma in a 66-year-old male who had a 5-year history of diffuse large B cell lymphoma on the left inguinal lymph node. The patient visited our clinic for the first time for relief of a non-tender well-defined erythematous hard nodules on the left foot and left thigh that had been present form 6 months and 1 month, respectively. Histologic examination revealed diffuse dense infiltration of large neoplastic lymphocytes with scanty cytoplasm and large nuclei. They showed a positive reaction to CD20 and CD79a, suggesting a B cell lineage. The patient was diagnosed with secondary cutaneous diffuse large B cell lymphoma. After 1 month of radiation therapy, complete remission was achieved. Five and seven months later, the patient returned foe relief of non-tender red-to-brown hard nodules on the left and right thigh, respectively. Histologic examination and immunohistochemical stain prompted the same diagnosis as previously. After radiotherapy and chemotherapy, the skin lesion was nearly resolved, and no evidence of extracutaneous involvement has been noted since. (Korean J Dermatol 2011;49(11):1041∼1045)
김의경 ( Ui Kyung Kim ),남현민 ( Hyun Min Nam ),박세영 ( Se Young Park ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Unilateral acanthosis nigricans (AN) is an exceedingly rare disorder, probably viewed as a nevoid disorder and sometimes called nevoid AN, which is characterized by hyperkeratosis, papillomatosis and moderate acanthosis. The lesions of unilateral AN are distributed unilaterally and morphologic features are similar to other forms of AN. It is not associated with a syndrome, endocrinopathy, drugs or cancers. Here we describe a case of unilateral AN in a 16 year-old Korean man who presented with a broad ashy brown hyperpigmented, confluent hyperkeratotic plaque on the right posterior thigh.
김의경 ( Ui Kyung Kim ),권선용 ( Seon Yong Kwon ),남현민 ( Hyun Min Nam ),박석돈 ( Seok Don Park ),박건 ( Kun Park ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.6
Malignant fibrous histiocytoma (MFH) is an aggressive soft-tissue sarcoma that most commonly occurs in the skeletal muscle of the extremities or retroperitoneum of the middle and late adulthood. We present a case of a 65-year-old woman who was presented with an asymptomatic erythematous nodule with central erosion on left temporal area. She was diagnosed with MFH, and then underwent Mohs micrographic surgery and flap coverage. No sign of metastatic recurrence was noted during the 6 month follow-up period.
귀먹음이 동반된 가변 홍색각질피부증(Erythrokeratodermia Variabilis)
남현민 ( Hyun Min Nam ),김의경 ( Ui Kyung Kim ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.4
Erythrokeratodermia variabilis is a rare genodermatosis characterized by the coexistence of randomly occurring, transient, erythematous patches and hyperkeratosis of the skin. A 25-year-old Uzbekistanian female with congenital deaf-mutism presented with well demarcated geographic hyperkeratotic patches and bizarre erythema on the whole body surface except the face, hands and feet from birth. The histopathological examination revealed marked hyperkeratosis, moderate acanthosis in the epidermis and vascular dilatation with a perivascular infiltration of inflammatory cells in the upper dermis. Herein we report on a rare case of erythrokeratodermia variabilis with congenital deaf-mutism which was rapidly improved by administering acitretin. (Korean J Dermatol 2011;49(4):379∼381)
후천천공피부병 환자에서 Allopurinol 투여 후 발생한 피부 부작용으로 오인한 딱지옴
남현민 ( Hyun Min Nam ),김의경 ( Ui Kyung Kim ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.3
Crusted (Norwegian) scabies is a clinical variant of human infestation with Sarcoptes scabiei, and is characterized by extensive, heavily crusted skin lesions. It usually affects immunocompromised patients. The diagnosis is commonly missed, and can lead to mismanagement. Here we report a case of crusted scabies misdiagnosed as a cutaneous side reaction due to allopurinol in a 48 year old male patient with acquired perforating dermatosis who had been treated with allopurinol for about 20 weeks. The lesion showed pruritic, excessive hyperkeratotic scaly crusts and fissures on the hands, and on pelvic, genital and inguinal areas. His skin lesions disappeared after treatment with 10% crotamiton cream for 2 weeks. (Korean J Dermatol 2011;49(3):287∼290)
김도현 ( Do Hyeon Kim ),김의경 ( Ui Kyung Kim ),최금하 ( Keum Ha Choi ),박건 ( Kun Park ) 대한피부과학회 2019 大韓皮膚科學會誌 Vol.57 No.2
Background: Keloids are the result of an overgrowth of dense fibrous tissue. The mechanisms involved in keloid formation remain unknown. Objective: To understand the mechanism of keloid formation, differences in gene expression in keloids and normal skin were compared. Gene expression profiles of keloids and normal skin were analyzed. Methods: From microarray analysis, eight genes whose expression profiles showed down-regulation or up-regulation in keloid samples were selected and the expression of these genes were confirmed by real-time polymerase chain reaction to further shed light on the mechanism of keloid formation. Results: The expression levels of FBXO32, NTF3, MEGF6, and ITGA8 were significantly increased in cells isolated from keloid tissue, whereas the expression levels of PTGS2, PITX1, MALL, and AMFR were significantly decreased in keloids compared to normal skin. Conclusion: These differently expressed genes in keloids and normal skin may play an important role in keloid formation. (Korean J Dermatol 2019;57(2):59∼65)
권선용 ( Sun Yong Kwon ),박상현 ( Sang Hyun Park ),김의경 ( Ui Kyung Kim ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.8
Nevus lipomatosus cutaneous superficialis (NLCS) is an uncommon form of connective tissue nevus, which is manifested principally as the deposition of fatty tissue in the dermis. Lesions almost always arise unilaterally on the thigh or buttock. Although NLCS can affect any region of the skin, only five cases of NLCS on face have been reported. A 48-year-old female presented with a skin-colored, 1 cm sized, soft and edematous plaque on the right malar area. The histopathologic findings showed scattered ectopic fat lobules between collagen fibers in the mid to deep dermis. We herein reported a case of solitary and plaque-shaped NLCS on the malar area. (Korean J Dermatol 2013;51(8):620∼622)
권선용 ( Sun Yong Kwon ),박상현 ( Sang Hyun Park ),김의경 ( Ui Kyung Kim ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.7
Clear cell basal cell carcinoma is a rare histological variant of basal cell carcinoma, which is characterized by a variable component of clear cells. We report a case of clear cell basal cell carcinoma in a 53-year-old Caucasian male presented with a red 0.7×0.6 cm sized nodule with central bleeding on left cheek for 2 years. Histological examinations showed multiple dermal tumor lobules nested with basaloid cells of a peripheral palisading pattern. In addition, prominent clear cell changes were observed in the center of large nests. The clear cells showed a single large vacuole in their eosinophilic and granular cytoplasm with eccentric condensed nucleus. The clear tumor cells was stained with periodic acid Schiff and showed incomplete diastase-resistance. Intercellular mucin staining with alcian blue was positive. The tumor was successfully treated with Mohs micrographic surgery and no recurrence has been observed for 6 months. (Korean J Dermatol 2013;51(7):548∼551)