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카테콜기로 치환된 글리콜 키토산의 젤화거동 및 자가치유능
정소윤(So Yun Jeong),김은우(Eunu Kim),박원호(Won Ho Park) 한국고분자학회 2020 폴리머 Vol.44 No.2
글리콜 키토산은 키토산의 친수성 유도체로서 무독성, 생체적합성 및 생분해성을 가지며, 넓은 범위의 pH 조건의 수용액에서 우수한 용해성을 나타내는 친수성 다당류이다. 따라서 글리콜 키토산은 키토산과는 달리 중성 pH조건의 수용액에서 용해가 가능하기 때문에 생체재료 분야에서 연구가 활발히 진행되고 있다. 한편, 자가치유 수화젤은 외력에 의해 파괴된 가교구조를 원래대로 회복할 수 있는 능력을 가진 수화젤을 의미한다. 이는 수소결합과 같은 물리적 결합 혹은 이민결합과 같은 화학적 결합을 통해 제조할 수 있으며, 조직공학용 재료 및 약물전달시스템 등에서 응용되고 있다. 본 연구에서는 이민결합 형성을 위해 글리콜 키토산에 카테콜기를 도입하여 자가치유 특성을 가지는 수화젤을 제조하였다. 또한 농도, 치환도 및 pH에 따른 젤화거동의 변화와 자가치유능을 분석하여 생체재료로서의 적용가능성을 살펴보았다. Glycol chitosan (GC) is a hydrophilic derivative of chitosan, and has non-toxic, biocompatible, and biodegradable properties. Also, GC shows excellent solubility under a wide range of pH conditions. Therefore, it is widely studied in various biomedical fields due to the excellent solubility. The self-healing hydrogel means that the hydrogel could restore its structure and functionality after damage. This self-healing behavior can be achieved by the dynamic chemical bonds including imine bond as well as the physical bonds including hydrogen bond, and can be applicable to scaffolds for tissue engineering and drug delivery systems. In this study, the catechol-modified GC (GC-CA) conjugate was synthesized, and its self-healing hydrogel was prepared via Schiff’s base (-CH=N-) formation of GC-CA conjugate. The gelation behavior and self-healing properties of the GC-CA hydrogel were dependent on the various conditions, such as polymer concentration, degree of substitution, and pH. The results indicate that the GC-CA hydrogel will be applicable to self-healing biomaterials and tissue engineering scaffolds.
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국내 시판 일부 구강 양치액의 Streptococcus mutans 바이오필름 형성 억제 효과
이은송 ( Eun Song Lee ),강시묵 ( Si Mook Kang ),김은우 ( Eunu Kim ),권호근 ( Ho Keun Kwon ),김백일 ( Baek Il Kim ) 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.3
Objectives. The aim of this in vitro study was to evaluate the inhibitory effects of several commercially available antibacterial oral rinses on S. mutans biofilm formation. Methods. In this study, four commercial oral rinses produced in Korea containing different antibacterial substances (benzethonium chloride, cetylpyridinium chloride, chlorhexidine, and essential oil) were selected for assessment. Sterile distilled water and 0.1% chlorhexidine solution were used as a negative and a positive control, respectivery The planktonic S. mutans (107 CFU/ml) was mixed with the experimental oral rinses for 1 minute and the live cells were counted as a colonies forming unit (CFU). Also, the antibacterial effect of oral rinses were tested by a S. mutans biofilm model with the artificial saliva, THYE medium, and hydroxyapatite (HA) discs. The S. mutans biofilm was formed on an HA disc coated with artificial saliva for 64 hours. The medium was replaced every 24 hours, and the cultured biofilm was treated with each oral rinse for either 1 or 5 minutes, 3 times a day for two days. Also, the number of live cells in the biofilm were counted and denoted as CFU. Results. All four commercial oral rinses elicited significant antibacterial effects on planktonic S. mutans, showing more than 99% of CFU reduction. However, only Hexamedine oral rinse primarily composed of chlorhexidine exhibited a significant antibacterial effect on S. mutans biofilm. Conclusions. The antibacterial effects of the commercial oral rinses were less pronounced in biofilm than in the planktonic cells, and they varied among different products.
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