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- 저자 : 김서광 ( Shu Guang Jin ) (검색결과 1 건)
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기초 :In Situ Film Zymography를 이용한 신경교종의 기질 금속단백분해효소 활성도 관찰
김서광 ( Shu Guang Jin ),정신 ( Shin Jung ),문경섭 ( Kyung Sub Moon ),김인영 ( In Young Kim ),배검 ( Jian Pei ),정태영 ( Tae Young Jung ) 대한뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.1
Introduction:Glioma is a common brain tumor, during the initial stage of oncogenesis, there are both invasions of normal tissues nearby and metastasis to contralateral cerebral hemisphere. Among the tumor invasion factors, matrix metalloproteinases( MMPs) facilitates the invasiveness of tumor cells and is highly expressed in malignant brain tumors. This study is to investigate the level of MMP expression, its location in glioma, using in situ film zymography. Materials and Methods:Thirteen glioblastoma samples and 5 oligodendroglioma samples were studied. Using in situ film zymography method, we classified the MMP expression into 4 patterns, such as tumor center, margin, both(center & margin), and negative. Results:In glioblastoma samples, 10 samples(76.9%) were positive. Among them, 7 expressed the pattern of margin. In 5 oligodendroglioma samples, only one anaplastic oligodendroglioma which was transformed from oligodendroglioma, expressed as marginal pattern. There was no MMPs expression in normal brain tissues. Conclusion:The conclusion of this study is that MMPs highly expressed in glioblastoma, and mostly in the pattern of margin. MMPs is thought to be secreted by tumor cells and it may be practical of using MMP inhibitor during the treatment of glioma patients.
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