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수종의 한약재 열수추출물이 멜라토닌 수용체 발현에 미치는 영향
김보라미 ( Bo Ra Mi Kim ),양동호 ( Dong Ho Yang ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2007 동의신경정신과학회지 Vol.18 No.1
Objective : This study was to investigate the effects of several herbs on the levels of MT1 and MT2 melatonin receptorsMethods : For this study, we carried out dementia assessment examination of 34 patients with memory disturbance who have come to Cheongju oriental hospital of Daejeon university from April 2005 to February 2006. This study classified the patients as none-dementia(ND), questionable dementia(QD), and dementia(DA) groups and analyzed the result of examination. Results : 1. The water extracts of Dimocarpus long (WEDL) induced the levels of MT2 melatonin receptor expression in a concentration-dependent manner without altering the levels of MT1 melatonin receptor expression. 2. The treatment with the water extract of Zizyphus vulgaris (WEZV) induced the levels of MT1 melatonin receptor expression and the levels of MT2 melatonin receptor expression was not affected. 3. The levels of MT1 as well as MT2 melatonin receptor expression were markedly up-regulated in the water extract of Fossilia ossis (WEFO) and the water extract of Ostreae caro (WEOC)-treated C6 cells. 4. The combination treatment with WEDL and WEZV induced not only the levels of MT1 melatonin receptor expression but also MT2 melatonin receptor expression, but the synergic effects of the combination treatment with WEFO and WEOC were not detected in C6 cells. Conclusion : The study provides important new insights into the possible mechanisms on the regulation of melatonin receptor synthesis by WEDL, WEZV, WEFO and WEOC.
전광(癲狂) 유사 증상을 나타낸 화병(火病) 환자 치험 1례
양동호 ( Dong Ho Yang ),김보라미 ( Bo Ra Mi Kim ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.3
Hwa-byung is said as a Korean folk syndrome in DSM-Ⅳ,and that is translated into ``Anger syndrome``. In Oriental Medicine, Hwa-Byung is related with clonic emotional-stress, and include symptoms having the character of ``fire``.In this case, the patient had symptoms similar with schizophreniform disorder. We treated the patient with Sihoukan-tang, Ssanghwa-tang and Ziunkoron. And her condition was improved through these oriental medical treatment.