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김별하나,김영,정영미,고원건,정지홍 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Diabetic ulcer is one of the most common complications for patients with diabetes. It is difficult to treat since high blood sugar increases blood viscosity, which leads to insufficient nutrient supply towards nerves within the defect site. Specifically, over-expressed reactive oxygen species (ROS) accelerates advanced glycation end products (AGEs) by affecting glucose level, leading to blood supply disorders and chronic skin disease. In this study, a novel kraft lignin based antioxidant hydrogel was fabricated. Kraft lignin was introduced to gelatin matrix (Klig-Gel) and cross-linked via epoxidation. The chemical structure of kraft lignin chelates ferrous iron (Fe2+), which is the main factor that increases ROS expression though the Fenton reaction. Klig-Gel hydrogel was able relieve oxidative stress and inhibit over-oxidation process effectively. Therefore, it shows possibility to normalize the balance between natural antioxidant and ROS, and enhance diabetic ulcer treatment.
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Complex Coacervate as a Localized Drug Delivery and Adhesive Coating for Wound Healing Patches
김영,김별하나,정영미,이강원,정지홍 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Complex coacervation is a liquid-liquid phase separation, or liquid droplets formation, phenomenon that occurs when two oppositely charged macromolecules are interacting for net charge neutralization. From food additives to biotechnology, coacervates are applied in various research areas. From our previous studies, fucoidan, a marine-derived glycosaminoglycan, and poly-l-lysine (PLL) coacervates have shown promising protein delivery; sustained release profile, superior encapsulation ability, biocompatibility, and protection against harsh in-vivo environment, for cancer immunotherapy and tissue engineering applications. In this study, to surpass current wound healing patches, fucoidan was functionalized with dopamine (DOPA) to synthesize adhesive coacervate coating. DOPA conjugated fucoidan-PLL coacervate was successfully coated onto collagen sponge homogeneously. The coacervate coated collagen sponge showed promising adhesive and drug releasing properties for wound healing application.
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