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Acanthosis Nigricans, Tripe Palms, Florid Cutaneous Papillomatosis 소견을 보인 피부 부종양 증후군 3예
정도상 ( Jeong Do Sang ),오창근 ( O Chang Geun ),이재봉 ( Lee Jae Bong ),김문범 ( Kim Mun Beom ),장호선 ( Jang Ho Seon ),권경술 ( Kwon Gyeong Sul ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.10
Cutaneous paraneoplastic syndromes are the non-contiguous skin and mucous membrane changes that are caused by internal malignancy. since they may be the first sign of a new or recurrent malignancy, recognizing their features and clinical implication is very important, We describe three patients with internal malignancy such as stomach adenocarcinoma or biliary tract adenocarcinoma who showed coexistence of acanthosis nigricans, tripe palms, and cutaneous florid papillomatosis. We reviewed the literatures about these cutaneous paraneoplastic syndromes and discussed their relationship between this striking cutaneous manifestations and internal malignancy.(Korean J Dermatol 2003;41(10) : 1364~1369)
정도상 ( Jeong Do Sang ),조주현 ( Jo Ju Hyeon ),이재봉 ( Lee Jae Bong ),김문범 ( Kim Mun Beom ),오창근 ( O Chang Geun ),장호선 ( Jang Ho Seon ),권경술 ( Kwon Gyeong Sul ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.1
N/A Background: Many dermatologists usually prescribe antibiotics postoperatively to prevent the wound infection, but there are no definite guidelines for the use of prophylactic antibiotics in skin biopsy. Objective: The purpose of this study is to evaluate the efficacy of prophylactic antibiotice after skin biopsy. Methods: We performed the prospective study of 200 patients in skin biopsy. We excluded patients who have a risk failure, chronic hepatic failure, anemia, internal malignancy, untreated diabetes, immune suppression, taken antibiotic within 1 week, hypersensitivity to antibiotics and infected wound. They were classified randomly into two troups, each 100 patients with or without antibiotic prophylaxis. All patient received the wound dressing. All biopsy wounds were evaluated in a blinded fashion at the time of suture removal and scored according to a standardized assessment based on erythema, edema and discharge. Results: Of the 100 patients who received the wound dressing and the prophylactic antibiotics postoperatively, no one had surgical wound infection. Of the 100 patients who received only the wound dressing, one patient had surgical wound infection. Conclusion: The infection rates were not significantly differnet between two groups. Therefore prophylactic antibiotics after skin biopsy may not be necessary to prevent wound infection in healthy patients. (Korean J Dermatol 2004;42(1):16~22)
에스트로겐과 Isoflavone이 교원질 합성에 미치는 영향
김병균 ( Kim Byeong Gyun ),오창근 ( O Chang Geun ),조주현 ( Jo Ju Hyeon ),이재봉 ( Lee Jae Bong ),김문범 ( Kim Mun Beom ),장호선 ( Jang Ho Seon ),권경술 ( Kwon Gyeong Sul ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.8
N/A Background : The aging of skin is influenced by genetic, environmental, and hormonal factors. Estrogens are the missing player in the skin of postmenopausal women. In postmenopausal women, loss of collagen was related to decreased estrogen level. Phytoestrogens, i.e. isoflavone, are plant compounds with estrogen-like biologic activities. Objective : The effects of 18β-estradiol, and isoflavones on production of type Ⅰ collagen in the fibroblast of postmenopausal woman, keloid and Detroit cell line were examined. Methods : Type Ⅰ collagen was measured with procollagen type Ⅰ C-peptide EIA KIT. Results : 18β-estradiol and isoflavone enhanced the production of type Ⅰ collagen in cultured fibroblast of postmenopausal woman and keloid. But isoflavone inhibited the production of collagen in cultured fibroblast of Detroit cell. Conclusion : 18β-estradiol and isoflavone can prevent and improve the cutaneous alterations caused by loss of collagen of postmenopausal women. (Korean J Dermatol 2003;41(8) : 1041~1048)