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아토피피부염 환자에서 Zinc-alpha-2 Glycoprotein 함유 보습 제품의 치료 효능
김수민 ( Su Min Kim ),곡원호 ( Howard Chu ),이광훈 ( Kwang Hoon Lee ),박창욱 ( Chang Ook Park ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.9
Background: Patients with atopic dermatitis (AD) are vulnerable to xerosis due to impaired skin barrier function, which makes moisturizing essential. Recently, zinc-alpha-2 glycoprotein (ZAG) has appeared to modulate the skin barrier function in AD, and has been proposed as a potential therapeutic molecule in AD. Objective: This study aimed to evaluate the effects of a ZAG-containing moisturizer on restoration of the skin barrier and clinical improvement of AD. Methods: In this randomized, double-blind study, 42 patients (average age, 26.5 years) with mild-to-moderate AD were enrolled. The subjects were divided into two groups, ZAG-containing moisturizer or control, in which the intervention or control were applied twice a day for 4 weeks. The primary outcome was a change in the eczema area and severity index (EASI) after 4 weeks, and the secondary outcome included the transepidermal water loss (TEWL), corneometer, visual assessment score (VAS) for pruritus and sleep disturbance, and investigator’s global assessment (IGA). Results: ZAG-containing moisturizer was well-tolerated, with a significant decrease in the EASI score compared to the control group after 4 weeks of application (p<0.05). As objective assessments of skin barrier function, TEWL also showed a significant, rapid decrease in the ZAG group compared to the control group after 2 weeks of application (p<0.05). A significant improvement in AD symptoms was observed at 4 weeks, such as the VAS score for pruritus and sleep disturbance, and IGA. Conclusion: The moisturizer containing ZAG (By the doctor Ato repair cream<sup>Ⓡ</sup>, Whitecospharm, Korea) effectively restored the function of the skin barrier, which led to a relief in the signs and symptoms of AD. (Korean J Dermatol 2020;58(9):575∼582)
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강홍규 ( Hong Kyu Kang ),곡원호 ( Howard Chu ),김도영 ( Do Young Kim ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.8
Cryotherapy is one of the most widely used procedures in the field of dermatology. Since the development of cryotherapy with the use of liquid nitrogen beginning in the 19th century, its use has gradually increased for various dermatologic conditions, including benign conditions, premalignant lesions, and malignancies. Because the therapeutic effects of cryotherapy are diverse, it must be applied specifically for each indication, requiring a thorough understanding of the basic principles and mechanisms of cryotherapy. In addition, both acute and chronic complications can develop, which may possibly leave permanent scars and tissue damage, thus, careful manipulation is required. In conclusion, cryotherapy is a frequently used treatment method but should be performed precisely by well-trained specialists. (Korean J Dermatol 2016;54(8):595∼600)
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