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전국 1차 진료기관에서 의뢰된 피부종양 3738예의 통계적 고찰
서정화,정성태,이미우,성경제,임내인,고재경 ( Jung Wha Suh,Sung Tae Jung,Mi Woo Lee,Kyung Jeh Sung,Nae In Lim,Jai Kyoung Koh ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6
Background: Many stu iies focused on the distribution of skin tumors, but none of them included the data refered from primat y physicians in Korea. Objective : This study was to investigate the incidence and distribution of skin tumors among Korean people. Methods : A Total of 3738 cases of skin tumor biopsy specimens referred from primary physicians nationwide to Ewon Reference Laboratory(EWON) from July 1989 to June 1992 were reviewed with a microscope, and classified. The result was compared wit.h the data of skin tumor cases biopsied during the same period at the department of dermatology of Asan Medical Center (AMC). Results : 1. Of all skin turnors reviewed, malignant tumors were 3.9% at EWON and 11.0% at Asan Medical Center. 2. The most common primary malignant tumors of the skin were in the order of basal cell carcinoma, squamous cell ca 'cinoma, and malignant melanoma in both centers. 3. The most common benign tumors were in the order of epidermal cyst, lipoma, pilomatricoma, hemangioma, and dermatofibroma at EWON, and epidermal cyst, seborrheic keratosis, syringoma, pyogenic granuloma, derr iatofibroma and lipoma at AMC. 4. While the prevalence of benign skin tumors were highest in the fourt.h 8: fifth decades, that of malignant skin tumorware highest in the sixth & seventh decades. Conclusion : Our study shows that the data obtained from tertiary hospitals can be quite different from those of primaiy physicians and the incidence of malignant skin tumors can be overestirnated when only data from large university hospitals were included. (Korean J Dermatol 1997;35(6): 1168-1176)
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한국인에서의 전염성연속종 바이러스의 분자생물학적 역학에 관한 연구
최지호(Jee Ho Choi),김규한(Kyu Han Kim),김성범(Seong Beom Kim),서정화(Jung Wha Suh),고재경(Jai Kyoung Koh),성경제(Kyung Jeh Sung) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.5
Background : Recent restriction enclonuclease analysis studies hsve revealed that MCV DNA can be classified into two major types, designated MCV-1 and MCV-2, by th:ir restriction enzyme cleavsge patterns. In earlier reports of MCV DNA analysis, MCV-2 was the main virus type found in genital lesions. However many recent studies cienied the relationship between virus type and anatomical distribution. Objective : The purpose of this study was to examine the ratio of MCV-l to MCV-2 in Korean isolates of MCV DNA and the relationship between MCV subtypes and with clinical features such as anatomical location, age, sex, numiber of lesions, and atopic dermatitis. Methads : MCV DNA extrated from 112 cases of Korean patients waa examined by restriction endonuclease analysis using Brtm HI. Results : 1. MCV-1 was found in 108 of 112 (96.4%) patients and MCV-2 in of 112 (3.6%) patients. The ratio of MCV-1 to MCV-2 wss 28:1. 2. There was no significant ciprrelation between MCV subtypes and the age, sex, number of lesions, atopic dermatitis, and anatoimic loction. 3. Lesions induced by MCV-1 MCV-2 were indistinguishable on the brsis of size and form. Conclueion : This study showis that the ratio of MCV-1 to MCV-2 was 28:1 in Korean molluscum contagiosum patients and there was no relationship between MCV subtyies and lesional morphology or snatomical distribution. (Kor J Dermatol 1994;32(5):763-769)
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전염성 연속종의 임상적 고찰 및 지연형 피부면역반응 검사소견에 관한 연구
최지호,서정화,윤문수,성경제,고재경 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1
Molluscum contagiosum is a benign infectious acanthoma caused by molluscum contagiosum virus which has structural features intermediate between the orthopoxvirus group, e.g. vaccinia, and the parapoxvirus group, e.g. orf. There are few reports on the clinical and immunological features of molluscum contagiosum in Korea. This study was aimed to investigate the clinical manifestations of 207 molluscum patients and to evaluate the delayed cutaneous hypersensitivity responsiveness by the Multitest CMI kit(Pasteur Merieux) of 158 molluscum patients and 19 healthy persons as control. The results were summarized as follows : 1. The relative frequency of molluscum contagiosum on the hospital base in 1989-1992 was 1.1% and molluscum patients visited more frequently in winter and spring than summer and autumn. 2. Among 207 patients, 97(46.7%) were males and 110(53.1%) were female. The peak age of incidence was between 6-10 years of age and 83.6% were under 10 years of age. 3. The mean duration of skin lesion was 4.5 months and back was the most common in volved site(65.7%). 4. Atopic dermatitis(29%) was the most common combined skin disease and 43.9% of the patients had itching sensation. 5. The intensity of reaction(IR) and rate of reaction(RR) in molluscum patients were not significantly reduced than in controls.
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