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병원성 박테리아 검출용 헤테로다인 복조 기반 광섬유 바이오 센서
이슬이(Seul-Lee Lee),고영종(Youngjong Ko),김장현(Jang Hyun Kim),강현욱(Hyun Wook Kang),이용욱(Yong Wook Lee) 한국조명·전기설비학회 2020 조명·전기설비학회논문지 Vol.34 No.11
In this paper, we demonstrated an optical fiber biosensor based on heterodyne demodulation to detect five pathogenic bacteria species forming biofilms, such as Escherichia Coli, Vibrio Vulnificus, Pseudomonas Aeruginosa, Staphylococcus Aureus, and Streptococcus Iniae, with their fluorescence characteristics. The proposed sensor detects the fluorescence of the five bacteria species with the intrinsic fluorescence characteristics of amino acid tryptophan, whose excitation and emission wavelengths are 280 and 350 nm, respectively. The fabricated sensor consists of an UV light source for excitation of bacteria, a high sensitivity detector for detection of fluorescence signals emitted from the excited bacteria, and a lock-in amplifier for amplification of the detected fluorescence signals. The lock-in amplifier can remove various noise signals coupled with the desired fluorescence signals and amplify the magnitude of the desired signal through the heterodyne demodulation technique. This signal processing technique enables the detection of the weak picowatt (pW) fluorescence signals. Consequently, it is concluded that our sensor can successfully detect the intensity of the fluorescence signal emitted from five pathogenic bacteria species whose concentration lies within 10² to 10<SUP>7</SUP> CFU/ml.